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• W2049883956 abstract "In this study we show that IL-4 is crucial during reinforcement window of human Th2 differentiation for optimal Th2 development. We have also shown here that during this stage, IL-4 helps in cellular decision-making process of differentiation versus proliferation. We have combined computational and experimental methods to analyze Th2 transcription network to name novel players of the process of Th2 differentiation. Here we report that LIF through STAT3 negatively regulates Th2 differentiation. This approach can be generalized to analyze “omics” data to identify key regulatory modules." @default.
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• W2049883956 date "2012-06-18" @default.
• W2049883956 modified "2023-09-28" @default.
• W2049883956 title "Gene Set Enrichment Analysis Identifies LIF as a Negative Regulator of Human Th2 Cell Differentiation" @default.
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• W2049883956 doi "https://doi.org/10.1038/srep00464" @default.
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