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- W2049895116 abstract "The anatomical connectivity of ventrolateral frontal areas 44 and 45, which in the human brain constitute Broca's region, has been revisited on the basis of experimental anatomical tracer evidence in the nonhuman primate that the homologues of areas 44 and 45 have distinct bidirectional corticocortical connections. Here we show, using high angular resolution diffusion imaging in the living human brain, a dissociation between the specific projections from the pars opercularis (area 44) and the pars triangularis (area 45) in the ventrolateral frontal lobe. As in the macaque monkey, area 44 has distinct connections with the rostral inferior parietal lobule via the third branch of the superior longitudinal fasciculus. In contrast, area 45 connects with the superior temporal gyrus, anterior to Heschl's gyrus, via the extreme capsule fiber system. These results highlight the differences in connectivity between areas 44 and 45 which had previously been thought to be uniformly connected with the posterior temporal region via the arcuate fasciculus. We also provide evidence in the human brain that the arcuate fasciculus, as in the macaque monkey brain, connects the posterior superior temporal region with dorsolateral frontal areas 8 and rostral 6 that lie above areas 44 and 45. Thus, monkey and human evidence suggests that the connections of areas 44 and 45 are much more differentiated than had previously been thought and provide the basis for studies searching for their differential contribution in function." @default.
- W2049895116 created "2016-06-24" @default.
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- W2049895116 date "2008-11-05" @default.
- W2049895116 modified "2023-10-12" @default.
- W2049895116 title "Dissociating the Human Language Pathways with High Angular Resolution Diffusion Fiber Tractography" @default.
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- W2049895116 doi "https://doi.org/10.1523/jneurosci.2388-08.2008" @default.
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