FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049896110> ?p ?o ?g. }

• W2049896110 endingPage "246" @default.
• W2049896110 startingPage "238" @default.
• W2049896110 abstract "Diuron is carcinogenic to the rat urinary bladder at high dietary levels. The proposed mode of action (MOA) for diuron is urothelial cytotoxicity and necrosis followed by regenerative urothelial hyperplasia. Diuron-induced urothelial cytotoxicity is not due to urinary solids. Diuron is extensively metabolized, and in rats, N-(3,4-dichlorophenyl)urea (DCPU) and 4,5-dichloro-2-hydroxyphenyl urea (2-OH-DCPU) were the predominant urinary metabolites; lesser metabolites included N-(3,4-dichlorophenyl)-3-methylurea (DCPMU) and trace levels of 3,4-dichloroaniline (DCA). In humans, DCPMU and DCPU have been found in the urine after a case of product abuse. To aid in elucidating the MOA of diuron and to evaluate the metabolites that are responsible for the diuron toxicity in the bladder epithelium, we investigated the urinary concentrations of metabolites in male Wistar rats treated with 2500 ppm of diuron, the urothelial cytotoxicity in vitro of the metabolites and their gene expression profiles. DCPU was found in rat urine at concentrations substantially greater than the in vitro IC50 and induced more gene expression alterations than the other metabolites tested. 2-OH-DCPU was present in urine at a concentration approximately half of the in vitro IC50, whereas DCPMU and DCA were present in urine at concentrations well below the IC50. For the diuron-induced MOA for the rat bladder, we suggest that DCPU is the primary metabolite responsible for the urothelial cytotoxicity with some contribution also by 2-OH-DCPU. This study supports a MOA for diuron-induced bladder effects in rats consisting of metabolism to DCPU (and 2-OH-DCPU to a lesser extent), concentration and excretion in urine, urothelial cytotoxicity, and regenerative proliferation." @default.
• W2049896110 created "2016-06-24" @default.
• W2049896110 creator A5009972348 @default.
• W2049896110 creator A5011471622 @default.
• W2049896110 creator A5015373172 @default.
• W2049896110 creator A5024906356 @default.
• W2049896110 creator A5029395581 @default.
• W2049896110 creator A5056641503 @default.
• W2049896110 creator A5085762574 @default.
• W2049896110 date "2013-12-01" @default.
• W2049896110 modified "2023-10-10" @default.
• W2049896110 title "Diuron metabolites and urothelial cytotoxicity: In vivo, in vitro and molecular approaches" @default.
• W2049896110 cites W1964895626 @default.
• W2049896110 cites W1984643017 @default.
• W2049896110 cites W1995013024 @default.
• W2049896110 cites W2003618418 @default.
• W2049896110 cites W2004803487 @default.
• W2049896110 cites W2013134232 @default.
• W2049896110 cites W2056290881 @default.
• W2049896110 cites W2058830397 @default.
• W2049896110 cites W2069992064 @default.
• W2049896110 cites W2074036268 @default.
• W2049896110 cites W2081098333 @default.
• W2049896110 cites W2088666757 @default.
• W2049896110 cites W2105782301 @default.
• W2049896110 cites W2107277218 @default.
• W2049896110 cites W2109972881 @default.
• W2049896110 cites W2117863928 @default.
• W2049896110 cites W2122779315 @default.
• W2049896110 cites W2154401382 @default.
• W2049896110 cites W2156444615 @default.
• W2049896110 cites W2158390305 @default.
• W2049896110 cites W2167164222 @default.
• W2049896110 doi "https://doi.org/10.1016/j.tox.2013.10.005" @default.
• W2049896110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24172598" @default.
• W2049896110 hasPublicationYear "2013" @default.
• W2049896110 type Work @default.
• W2049896110 sameAs 2049896110 @default.
• W2049896110 citedByCount "26" @default.
• W2049896110 countsByYear W20498961102014 @default.
• W2049896110 countsByYear W20498961102015 @default.
• W2049896110 countsByYear W20498961102016 @default.
• W2049896110 countsByYear W20498961102017 @default.
• W2049896110 countsByYear W20498961102018 @default.
• W2049896110 countsByYear W20498961102019 @default.
• W2049896110 countsByYear W20498961102020 @default.
• W2049896110 countsByYear W20498961102021 @default.
• W2049896110 countsByYear W20498961102022 @default.
• W2049896110 countsByYear W20498961102023 @default.
• W2049896110 crossrefType "journal-article" @default.
• W2049896110 hasAuthorship W2049896110A5009972348 @default.
• W2049896110 hasAuthorship W2049896110A5011471622 @default.
• W2049896110 hasAuthorship W2049896110A5015373172 @default.
• W2049896110 hasAuthorship W2049896110A5024906356 @default.
• W2049896110 hasAuthorship W2049896110A5029395581 @default.
• W2049896110 hasAuthorship W2049896110A5056641503 @default.
• W2049896110 hasAuthorship W2049896110A5085762574 @default.
• W2049896110 hasConcept C109316439 @default.
• W2049896110 hasConcept C114246631 @default.
• W2049896110 hasConcept C134018914 @default.
• W2049896110 hasConcept C150903083 @default.
• W2049896110 hasConcept C178790620 @default.
• W2049896110 hasConcept C185592680 @default.
• W2049896110 hasConcept C202751555 @default.
• W2049896110 hasConcept C207001950 @default.
• W2049896110 hasConcept C2777477808 @default.
• W2049896110 hasConcept C2780026642 @default.
• W2049896110 hasConcept C29730261 @default.
• W2049896110 hasConcept C55493867 @default.
• W2049896110 hasConcept C77411442 @default.
• W2049896110 hasConcept C86803240 @default.
• W2049896110 hasConcept C98274493 @default.
• W2049896110 hasConceptScore W2049896110C109316439 @default.
• W2049896110 hasConceptScore W2049896110C114246631 @default.
• W2049896110 hasConceptScore W2049896110C134018914 @default.
• W2049896110 hasConceptScore W2049896110C150903083 @default.
• W2049896110 hasConceptScore W2049896110C178790620 @default.
• W2049896110 hasConceptScore W2049896110C185592680 @default.
• W2049896110 hasConceptScore W2049896110C202751555 @default.
• W2049896110 hasConceptScore W2049896110C207001950 @default.
• W2049896110 hasConceptScore W2049896110C2777477808 @default.
• W2049896110 hasConceptScore W2049896110C2780026642 @default.
• W2049896110 hasConceptScore W2049896110C29730261 @default.
• W2049896110 hasConceptScore W2049896110C55493867 @default.
• W2049896110 hasConceptScore W2049896110C77411442 @default.
• W2049896110 hasConceptScore W2049896110C86803240 @default.
• W2049896110 hasConceptScore W2049896110C98274493 @default.
• W2049896110 hasIssue "2-3" @default.
• W2049896110 hasLocation W20498961101 @default.
• W2049896110 hasLocation W20498961102 @default.
• W2049896110 hasOpenAccess W2049896110 @default.
• W2049896110 hasPrimaryLocation W20498961101 @default.
• W2049896110 hasRelatedWork W1592261125 @default.
• W2049896110 hasRelatedWork W1982027601 @default.
• W2049896110 hasRelatedWork W2007357675 @default.
• W2049896110 hasRelatedWork W2073235663 @default.
• W2049896110 hasRelatedWork W2088203456 @default.
• W2049896110 hasRelatedWork W2189617136 @default.

• next