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- W2049901350 abstract "Penicillium brevicompactum ATCC 16024 produced 1.7 g/1 of mycophenolic acid (MPA) in the culture medium. Various drug-resistant mutants, showing resistance to such as polyene antibiotics, chemotherapeutic agents, redox indicator and surfactants, were derived from the fungus. Most of the mutants produced 2.0 ~2.5 g/1 of MPA. A clofibrate and dodecyltrimethylammonium chloride double resistant mutant, No. 4–23–11, produced 4.7 g/1 of MPA. A monofluoroacetic acid resistant strain, No. 5–1, derived from No. 4–23–11 produced 5.3 g/1 of MPA.A methionine auxotroph, M-l, derived from ATCC 16024, produced 4.0 g/1 of MPA. A glutamate auxotroph, G-42, derived from strain No. 4–23–11 produced 5.8 g/1 of MPA. G-42 grew on l-aspartate instead of l-glutamate, and showed one-third the pyruvate carboxylase activity of the parent. Another glutamate auxotroph, G-78, did not produce MPA but accumulated 1.5 g/1 of acetate in the culture medium, and showed one-fifth the citrate synthase activity of the parent strain." @default.
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- W2049901350 date "1987-09-01" @default.
- W2049901350 modified "2023-09-26" @default.
- W2049901350 title "Mycophenolic Acid Production by Drug-resistant and Methionine or Glutamic-Acid Requiring Mutants ofPénicillium brevicompactum" @default.
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- W2049901350 doi "https://doi.org/10.1080/00021369.1987.10868427" @default.
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