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- W2049907563 abstract "Chemical ventricular defibrillation of the human heart by intravenous administration of bretylium tosylate (5 to 10 mg/kg body weight) can be a lifesaving procedure when an electrical defibrillator is not immediately available. Bretylium rapidly restored both a stable rhythmic beat (usually sinus) as well as good mechanical contractions in six episodes of ventricular fibrillation occurring in five of seven patients in whom chemical defibrillation was attempted. Our experience suggests that bretylium should be given intravenously as soon as fibrillation is detected, raising the patient's arm above the heart while maintaining closed chest massage and ventilation if necessary. Bretylium appeared to facilitate resuscitation even in the two patients whose heart did not defibrillate chemically during the infusion since stable sinus rhythm was established after a single electrical countershock. No other drug has been shown to have this clinically useful direct defibrillatory capability with resultant patient survival. Chemical ventricular defibrillation of the human heart by intravenous administration of bretylium tosylate (5 to 10 mg/kg body weight) can be a lifesaving procedure when an electrical defibrillator is not immediately available. Bretylium rapidly restored both a stable rhythmic beat (usually sinus) as well as good mechanical contractions in six episodes of ventricular fibrillation occurring in five of seven patients in whom chemical defibrillation was attempted. Our experience suggests that bretylium should be given intravenously as soon as fibrillation is detected, raising the patient's arm above the heart while maintaining closed chest massage and ventilation if necessary. Bretylium appeared to facilitate resuscitation even in the two patients whose heart did not defibrillate chemically during the infusion since stable sinus rhythm was established after a single electrical countershock. No other drug has been shown to have this clinically useful direct defibrillatory capability with resultant patient survival." @default.
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- W2049907563 date "1973-12-01" @default.
- W2049907563 modified "2023-10-12" @default.
- W2049907563 title "Chemical ventricular defibrillation of the human heart with bretylium tosylate" @default.
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- W2049907563 doi "https://doi.org/10.1016/s0002-9149(73)80168-7" @default.
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