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• W2049917519 abstract "To the Editor: It was a delight to see another description of the association between vitamin D deficiency and pain in the medical literature. My colleagues and I published an early, if not the first, description of non-osteomalacia-related pain in the Archives of Internal Medicine in 19911Gloth III, FM Lindsay JM Zelesnick LB Greenough III, WB Can vitamin D deficiency produce an unusual pain syndrome?.Arch Intern Med. 1991; 151: 1662-1664Crossref PubMed Scopus (105) Google Scholar and recently reviewed this entity in the pain literature.2Gloth III, FM Handbook of Pain Relief in Older Adults: An Evidence-Based Approach. Humana Press, Totowa, NJ2003: 177Google Scholar Despite the wide circulation of the Archives, our study was apparently not recognized, even by many experts, as one could surmise by the absence of a reference to this important observation either in the article by Plotnikoff and Quigley3Plotnikoff GA Quigley JM Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain.Mayo Clin Proc. 2003; 78: 1463-1470Abstract Full Text Full Text PDF PubMed Scopus (539) Google Scholar or in the accompanying editorial by Holick.4Holick MF Vitamin D deficiency: what a pain it is [editorial].Mayo Clin Proc. 2003; 78: 1457-1459Abstract Full Text Full Text PDF PubMed Scopus (147) Google Scholar Although the authors’ reference to our JAMA article5Gloth III, FM Gundberg CM Hollis BW Haddad Jr, JG Tobin JD Vitamin D deficiency in homebound elderly persons.JAMA. 1995; 274: 1683-1686Crossref PubMed Scopus (420) Google Scholar was greatly appreciated, your readers might find our original article on the vitamin D deficiency pain syndrome helpful. Of note, we prefer the term vitamin D deficiency rather than hypovitaminosis. It has long been recognized that a physiological or biochemical aberration caused by a low vitamin status (or hypovitaminosis) constitutes a vitamin deficiency. Certainly, pain due to physiological mechanisms and other manifestations, eg, secondary hyperparathyroidism, justifies the term vitamin deficiency. Vitamin D Deficiency as a Contributor to Multiple Forms of Chronic Pain: In ResponseMayo Clinic ProceedingsVol. 79Issue 5PreviewGloth and Greenough note that they described non-osteomalacia-related pain in 1991. Indeed, the pain and devastating consequences of vitamin D deficiency have been documented in the scientific literature for more than 100 years.1–3 There is little distinction between the terms vitamin D deficiency and hypovitaminosis D, just as there is little difference between vitamin D intoxication and hypervitaminosis D. I agree that vitamin D deficiency may be better understood by physicians and that this is the preferable term when describing a patient who has a 25-hydroxyvitamin D level of less than 20 ng/mL. Full-Text PDF Vitamin D Deficiency as a Contributor to Multiple Forms of Chronic Pain: In ResponseMayo Clinic ProceedingsVol. 79Issue 5PreviewIn a 1991 article, Dr Gloth et al1 raised the question, “Can vitamin D deficiency produce an unusual pain syndrome?” They documented hyperesthesia worsened by light, superficial pressure, or even small increments of movement in 5 patients. This disorder appeared to resolve with vitamin D therapy and recur when vitamin D levels declined. Full-Text PDF" @default.
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• W2049917519 title "Vitamin D Deficiency as a Contributor to Multiple Forms of Chronic Pain" @default.
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