FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049920908> ?p ?o ?g. }

• W2049920908 endingPage "239" @default.
• W2049920908 startingPage "229" @default.
• W2049920908 abstract "The APC gene, originally identified as the gene for familial adenomatous polyposis (FAP), is now considered as the true gatekeeper of colonic epithelial proliferation. Its main tumor suppressing activity seems to reside in the capacity to properly regulate intracellular beta-catenin signaling. Most somatic APC mutations are detected between codons 1286 and 1513, the mutation cluster region (MCR). This clustering can be explained either by the presence of mutation-prone sequences within the MCR, or by the selective advantage provided by the resulting truncated polypeptides. Here, a Msh2-deficient mouse model (Msh2(delta 7N) ) was generated and bred with Apc(1638N) and Apc(Min) that allowed the comparison of the somatic mutation spectra along the Apc gene in the different allelic combinations. Mutations identified in Msh2(delta 7N/delta 7N) tumors are predominantly dinucleotide deletions at simple sequence repeats leading to truncated Apc polypeptides that partially retain the 20 a.a. beta-catenin downregulating motifs. In contrast, the somatic mutations identified in the wild type Apc allele of Msh2(delta 7N/delta 7N) /Apc(+/1638N) and Msh2(delta 7N/delta 7N) /Apc(+/Min) tumors are clustered more to the 5' end, thereby completely inactivating the beta-catenin downregulating activity of APC. These results indicate that somatic Apc mutations are selected during intestinal tumorigenesis and that inactivation of the beta-catenin downregulating function of APC is likely to represent the main selective factor." @default.
• W2049920908 created "2016-06-24" @default.
• W2049920908 creator A5028047183 @default.
• W2049920908 creator A5034748673 @default.
• W2049920908 creator A5045304162 @default.
• W2049920908 creator A5051658337 @default.
• W2049920908 creator A5054473426 @default.
• W2049920908 creator A5060659027 @default.
• W2049920908 creator A5063861355 @default.
• W2049920908 creator A5065537887 @default.
• W2049920908 creator A5068669060 @default.
• W2049920908 creator A5071920629 @default.
• W2049920908 date "2000-01-01" @default.
• W2049920908 modified "2023-09-27" @default.
• W2049920908 title "SomaticApc mutations are selected upon their capacity to inactivate the ?-catenin downregulating activity" @default.
• W2049920908 cites W1499807572 @default.
• W2049920908 cites W1500930737 @default.
• W2049920908 cites W1544046482 @default.
• W2049920908 cites W1544851750 @default.
• W2049920908 cites W1608100785 @default.
• W2049920908 cites W1967137553 @default.
• W2049920908 cites W1967205646 @default.
• W2049920908 cites W1967243795 @default.
• W2049920908 cites W1975993620 @default.
• W2049920908 cites W1979618971 @default.
• W2049920908 cites W1989970624 @default.
• W2049920908 cites W1990606472 @default.
• W2049920908 cites W1996302902 @default.
• W2049920908 cites W1999596748 @default.
• W2049920908 cites W2006718453 @default.
• W2049920908 cites W2018348035 @default.
• W2049920908 cites W2036369378 @default.
• W2049920908 cites W2036864436 @default.
• W2049920908 cites W2039661491 @default.
• W2049920908 cites W2055654424 @default.
• W2049920908 cites W2057830803 @default.
• W2049920908 cites W2068622682 @default.
• W2049920908 cites W2081758458 @default.
• W2049920908 cites W2118184847 @default.
• W2049920908 cites W2133024775 @default.
• W2049920908 cites W2146167376 @default.
• W2049920908 cites W2151150093 @default.
• W2049920908 cites W2162745362 @default.
• W2049920908 cites W2171080110 @default.
• W2049920908 doi "https://doi.org/10.1002/1098-2264(2000)9999:9999<::aid-gcc1033>3.0.co;2-r" @default.
• W2049920908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10992298" @default.
• W2049920908 hasPublicationYear "2000" @default.
• W2049920908 type Work @default.
• W2049920908 sameAs 2049920908 @default.
• W2049920908 citedByCount "89" @default.
• W2049920908 countsByYear W20499209082012 @default.
• W2049920908 countsByYear W20499209082013 @default.
• W2049920908 countsByYear W20499209082014 @default.
• W2049920908 countsByYear W20499209082015 @default.
• W2049920908 countsByYear W20499209082016 @default.
• W2049920908 countsByYear W20499209082019 @default.
• W2049920908 countsByYear W20499209082020 @default.
• W2049920908 countsByYear W20499209082023 @default.
• W2049920908 crossrefType "journal-article" @default.
• W2049920908 hasAuthorship W2049920908A5028047183 @default.
• W2049920908 hasAuthorship W2049920908A5034748673 @default.
• W2049920908 hasAuthorship W2049920908A5045304162 @default.
• W2049920908 hasAuthorship W2049920908A5051658337 @default.
• W2049920908 hasAuthorship W2049920908A5054473426 @default.
• W2049920908 hasAuthorship W2049920908A5060659027 @default.
• W2049920908 hasAuthorship W2049920908A5063861355 @default.
• W2049920908 hasAuthorship W2049920908A5065537887 @default.
• W2049920908 hasAuthorship W2049920908A5068669060 @default.
• W2049920908 hasAuthorship W2049920908A5071920629 @default.
• W2049920908 hasConcept C104317684 @default.
• W2049920908 hasConcept C121608353 @default.
• W2049920908 hasConcept C134305767 @default.
• W2049920908 hasConcept C134935766 @default.
• W2049920908 hasConcept C13514818 @default.
• W2049920908 hasConcept C153911025 @default.
• W2049920908 hasConcept C180754005 @default.
• W2049920908 hasConcept C2778237340 @default.
• W2049920908 hasConcept C2779115348 @default.
• W2049920908 hasConcept C2780814781 @default.
• W2049920908 hasConcept C501734568 @default.
• W2049920908 hasConcept C502942594 @default.
• W2049920908 hasConcept C526805850 @default.
• W2049920908 hasConcept C54355233 @default.
• W2049920908 hasConcept C555283112 @default.
• W2049920908 hasConcept C60748783 @default.
• W2049920908 hasConcept C86803240 @default.
• W2049920908 hasConceptScore W2049920908C104317684 @default.
• W2049920908 hasConceptScore W2049920908C121608353 @default.
• W2049920908 hasConceptScore W2049920908C134305767 @default.
• W2049920908 hasConceptScore W2049920908C134935766 @default.
• W2049920908 hasConceptScore W2049920908C13514818 @default.
• W2049920908 hasConceptScore W2049920908C153911025 @default.
• W2049920908 hasConceptScore W2049920908C180754005 @default.
• W2049920908 hasConceptScore W2049920908C2778237340 @default.
• W2049920908 hasConceptScore W2049920908C2779115348 @default.
• W2049920908 hasConceptScore W2049920908C2780814781 @default.
• W2049920908 hasConceptScore W2049920908C501734568 @default.
• W2049920908 hasConceptScore W2049920908C502942594 @default.

• next