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- W204992181 abstract "We tested whether metastatic tumor cells of the Lewis lung carcinoma (M-3LL) possess different cell surface antigens than cells of the local tumor (L-3LL). We demonstrated that syngeneic lymphocytes sensitized in culture against monolayers of M-3LL lysed M-3LL targets significantly more than they lysed L-3LL targets, and vice versa. Furthermore, spleen cells from tumor-bearing mice that had been transplanted with M-3LL cells, were cytotoxic to M-3LL targets significantly more than to L-3LL targets, and vice-versa. Anti M-3LL lymphocytes generated both in vitro and in vivo, but not anti L-3LL lymphocytes, reduced the production of lung metastases when inoculated with tumor cells to syngeneic recipients. M-3LL cells were found also to be more resistant to natural killer cells than L-3LL cells. These results are discussed with respect to the immunoselection processes which might control the formation and progression of tumor metastasis." @default.
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- W204992181 date "1979-01-01" @default.
- W204992181 modified "2023-09-27" @default.
- W204992181 title "ANTIGENIC DIFFERENCES EXIST BETWEEN CELL SURFACE ANTIGENS OF THE LOCAL TUMOR AND ITS METASTASES" @default.
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- W204992181 doi "https://doi.org/10.1016/b978-0-12-569650-0.50096-6" @default.
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