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• W2049940896 abstract "To assess whether vaccination against human papillomavirus (HPV) increases the risk of miscarriage.Pooled analysis of two multicentre, phase three masked randomised controlled trialsMulticentre trials in several continents and in Costa Rica.26 130 women aged 15-25 at enrolment; 3599 pregnancies eligible for analysis.Participants were randomly assigned to receive three doses of bivalent HPV 16/18 VLP vaccine with AS04 adjuvant (n=13 075) or hepatitis A vaccine as control (n=13 055) over six months.Miscarriage and other pregnancy outcomes.The estimated rate of miscarriage was 11.5% in pregnancies in women in the HPV arm and 10.2% in the control arm. The one sided P value for the primary analysis was 0.16; thus, overall, there was no significant increase in miscarriage among women assigned to the HPV vaccine arm. In secondary descriptive analyses, miscarriage rates were 14.7% in the HPV vaccine arm and 9.1% in the control arm in pregnancies that began within three months after nearest vaccination.There is no evidence overall for an association between HPV vaccination and risk of miscarriage.Clinical Trials NCT00128661 and NCT00122681." @default.
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• W2049940896 date "2010-03-02" @default.
• W2049940896 modified "2023-09-27" @default.
• W2049940896 title "Risk of miscarriage with bivalent vaccine against human papillomavirus (HPV) types 16 and 18: pooled analysis of two randomised controlled trials" @default.
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• W2049940896 doi "https://doi.org/10.1136/bmj.c712" @default.
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