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- W2049945103 abstract "Pyrazole alone does not affect catalase activity in vitro; however, its administration in vivo produces irreversible inhibition of catalase in rat liver and kidney but not in blood. The inhibition in the liver, after a 70 mg/kg single dose of pyrazole, follows first-order kinetics with a half-life of 8 hr. The activity reaches a minimum at 28 hr followed by gradual recovery at a rate corresponding to a half-life of 1.19 days. This value agrees with previous half-life determinations for rat liver catalase; therefore it is taken as evidence that the irreversibility of the inhibition demonstrated in vitro is also maintained in vivo. The inhibition of catalase is mediated by a product from the metabolism of pyrazole by the microsomal mixed-function oxidase system. This active pyrazole derivative presumably reacts with catalase hydrogen peroxide complex I, and not with the native catalase, in a process that can be prevented by alcohol. It is shown that pyrazole, a drug also used as an alcohol dehydrogenase inhibitor, is eliminated from the liver in a simple exponential process with a half-life of 3.45 hr, which agrees with its reported effects on ethanol metabolism in vivo." @default.
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- W2049945103 date "1974-04-01" @default.
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- W2049945103 title "Effect of pyrazole on rat liver catalase" @default.
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- W2049945103 doi "https://doi.org/10.1016/0006-2952(74)90332-3" @default.
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