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- W2049948693 abstract "The effects of dantrolene sodium (DAN) on the dihydropyridine receptor (DHPR) of the transverse (T) tubule voltage sensor (Ca 2+ channel) was studied with single fibers from bullfrog toe muscle. Perchlorate [Formula: see text], which acts selectively on the DHPR, overcame DAN-induced inhibition of twitch tension. Bay K 8644, a DHPR agonist, slowed the rate of twitch inhibition by DAN. DAN inhibited twitch tension to a greater extent in Ca 2+ -free solution than in Ringer solution or solution containing Zn 2+ , whereas twitch inhibition by DAN was less in caffeine-containing solution than in the control. The effects of DAN on Zn 2+ - and caffeine-treated fibers and on fibers in Ca 2+ -free solution suggest that DAN must act near the voltage sensor of the T tubule. However, differences in net twitch inhibition by DAN between control fibers and fibers potentiated by [Formula: see text] or Bay K 8644 suggest that DAN does not bind to the same site as these potentiating agents do. The role of myoplasmic Ca 2+ in DAN-induced inhibition of twitch and the effects of DAN on the mechanical threshold and membrane potential in skeletal muscle are discussed.Key words: dantrolene sodium, perchlorate, Bay K 8644, twitch tension." @default.
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- W2049948693 date "1992-02-01" @default.
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- W2049948693 title "Partial inhibition of skeletal muscle contraction by dantrolene sodium and its modification with perchlorate and Bay K 8644" @default.
- W2049948693 doi "https://doi.org/10.1139/y92-028" @default.
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