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• W2049952007 abstract "Postoperative cognitive dysfunction or decline (POCD) is increasingly recognized as a common phenomenon after major surgery [ 1 Williams-Russo P. Sharrock N. Mattis S. et al. Cognitive effects after epidural vs general anesthesia in older adults. JAMA. 1995; 274: 44-50 Crossref PubMed Scopus (365) Google Scholar , 2 Moller J. Cluitmans P. Rasmussen L. et al. ISPOCD investigators: long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet. 1998; 351: 857-861 Abstract Full Text Full Text PDF PubMed Scopus (1809) Google Scholar , 3 Johnson T. Monk T. Rasmussen L.S. et al. Postoperative cognitive dysfunction in middle-aged patients. Anesthesiology. 2002; 96: 1351-1357 Crossref PubMed Scopus (337) Google Scholar , 4 Rasmussen L.S. Johnson T. Kuipers H.M. et al. Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients. Acta Anaesthesiol Scand. 2003; 47: 260-266 Crossref PubMed Scopus (444) Google Scholar ]. Because older age is a strong preoperative risk factor of POCD [ 2 Moller J. Cluitmans P. Rasmussen L. et al. ISPOCD investigators: long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet. 1998; 351: 857-861 Abstract Full Text Full Text PDF PubMed Scopus (1809) Google Scholar , 5 Monk T.G. Weldon B.C. Garvan C.W. et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008; 108: 18-30 Crossref PubMed Scopus (1032) Google Scholar ], the incidence of POCD is expected to increase as the population of older surgical patients grows. Improving the measurement of POCD and identifying its etiology is clinically important, as recent studies have associated POCD with impairments in daily functioning [ [6] Phillips-Bute B. Mathew J.P. Blumenthal J.A. et al. Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery. Psychosom Med. 2006; 68: 369-375 Crossref PubMed Scopus (156) Google Scholar ], premature departure from the labor market [ [7] Steinmetz J. Christensen K.B. Lund T. et al. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009; 110: 548-555 Crossref PubMed Scopus (709) Google Scholar ], and dependency on government economic assistance after hospital discharge [ [7] Steinmetz J. Christensen K.B. Lund T. et al. Long-term consequences of postoperative cognitive dysfunction. Anesthesiology. 2009; 110: 548-555 Crossref PubMed Scopus (709) Google Scholar ]." @default.
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• W2049952007 date "2010-01-01" @default.
• W2049952007 modified "2023-09-27" @default.
• W2049952007 title "An Update on Postoperative Cognitive Dysfunction" @default.
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