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- W2049953555 abstract "Male sexual behavior is mediated in part by androgens, but in several species, mating is also influenced by estradiol formed locally in the brain by the aromatization of testosterone. The role of testosterone aromatization in the copulatory behavior of male Syrian hamsters is unclear because prior studies are equivocal. Therefore, the present study tested whether blocking the conversion of testosterone to estradiol would inhibit male hamster sexual behavior. Chronic systemic administration of the nonsteroidal aromatase inhibitor Fadrozole (2.0 mg/kg/day) for 5 or 8 weeks did not significantly increase mount latency or reduce mount frequency, intromission frequency, ejaculation frequency, or anogenital investigation relative to levels shown by surgical controls. However, Fadrozole effectively inhibited aromatase activity, as evidenced by the suppression of estrogen-dependent progesterone receptor immunoreactivity in the male hamster brain. The JZB39 anti-progesterone receptor antibody labeled significantly more neurons in brains of sham-treated hamsters than in brains of Fadrozole-treated hamsters. These data suggest that aromatization of testosterone to estradiol is not necessary for normal mating behavior in Syrian hamsters." @default.
- W2049953555 created "2016-06-24" @default.
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- W2049953555 date "2000-05-01" @default.
- W2049953555 modified "2023-10-13" @default.
- W2049953555 title "Conversion of Testosterone to Estradiol May Not Be Necessary for the Expression of Mating Behavior in Male Syrian Hamsters (Mesocricetus auratus)" @default.
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- W2049953555 doi "https://doi.org/10.1006/hbeh.2000.1579" @default.
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