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- W2049955081 abstract "Polyethylene glycol (PEG)-liposomal doxorubicin (Stealth R, Doxil) is a formulation of doxorubicin, which is encapsulated in liposomes formulated with PEG. It is favored in the palliative setting over doxorubicin because of its generally favorable side effect profile. Adverse reactions are predominantly skin eruptions. We report 3 cases of women with breast cancer undergoing treatment with liposomal doxorubicin who developed palmar-plantar erythrodysesthesia and diffuse morbilliform eruptions. Biopsies in the 2 cases demonstrated vacuolar interface dermatitis with epidermal dysmaturation and the third case suggested a drug eruption. Additionally, we report a woman with metastatic breast cancer who developed a similar morbilliform eruption soon after completing a regimen of liposomal doxorubicin. The biopsy revealed an atypical squamous proliferation showing epidermal dysmaturation with focal evidence of interface damage. Both clinician and pathologist alike should be cognizant of this cutaneous eruption, as well as the histologic patterns." @default.
- W2049955081 created "2016-06-24" @default.
- W2049955081 creator A5005572678 @default.
- W2049955081 creator A5046161744 @default.
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- W2049955081 date "2006-04-01" @default.
- W2049955081 modified "2023-10-14" @default.
- W2049955081 title "Histologic Patterns of Polyethylene Glycol-liposomal Doxorubicin-related Cutaneous Eruptions" @default.
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- W2049955081 doi "https://doi.org/10.1097/01.dad.0000199880.71481.0f" @default.
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