FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049958615> ?p ?o ?g. }

• W2049958615 endingPage "1326" @default.
• W2049958615 startingPage "1319" @default.
• W2049958615 abstract "Background Herpes simplex virus (HSV) causes significant health problems from periodical skin and corneal lesions to encephalitis. HSV entry provides a unique opportunity for therapeutic intervention. In this study, we evaluated contortrostatin (CN), an Arg-Gly-Asp motif containing disintegrin isolated from snake venom, as a novel therapeutic agent with ability to block HSV entry and related membrane fusion. Methods In vitro efficacy of CN against HSV was determined using an HSV type-1 (HSV-1) entry assay based on the measurement of β-galactosidase reporter activity originating from the genome of a recombinant strain of HSV-1(KOS) gL86. HSV-1 glycoprotein-mediated cell-to-cell fusion was used to study the effect of CN on polykaryocyte formation. Primary as well as transformed cell lines were used for this study. Results Pre-treatment of Chinese hamster ovary (CHO-K1) cells expressing HSV-1 glycoprotein D receptors and primary cultures of human corneal fibroblasts (CF) with CN resulted in the inhibition of entry, cell-to-cell fusion, and polykaryocyte formation. Interestingly, a more pronounced anti-HSV-1 effect was observed in naturally susceptible CF than CHO-K1 cells. Conclusions CN, a novel venom-derived peptide, exhibits the ability to block two key steps, entry and cell-to-cell fusion, in HSV infection. Showing strong promise for development as an anti-HSV agent, it also demonstrates better prophylactic efficacy in primary cells." @default.
• W2049958615 created "2016-06-24" @default.
• W2049958615 creator A5001344640 @default.
• W2049958615 creator A5007357880 @default.
• W2049958615 creator A5045849567 @default.
• W2049958615 creator A5054474510 @default.
• W2049958615 creator A5058989459 @default.
• W2049958615 creator A5065970650 @default.
• W2049958615 creator A5076097951 @default.
• W2049958615 date "2012-10-01" @default.
• W2049958615 modified "2023-09-30" @default.
• W2049958615 title "Contortrostatin, a Homodimeric Disintegrin Isolated from Snake Venom Inhibits Herpes Simplex Virus Entry and Cell Fusion" @default.
• W2049958615 cites W1921145068 @default.
• W2049958615 cites W1967616351 @default.
• W2049958615 cites W1972543205 @default.
• W2049958615 cites W1979385877 @default.
• W2049958615 cites W1988570956 @default.
• W2049958615 cites W1996780355 @default.
• W2049958615 cites W2001371234 @default.
• W2049958615 cites W2007639993 @default.
• W2049958615 cites W2008486572 @default.
• W2049958615 cites W2025851253 @default.
• W2049958615 cites W2027657241 @default.
• W2049958615 cites W2032598362 @default.
• W2049958615 cites W2037405042 @default.
• W2049958615 cites W2040432364 @default.
• W2049958615 cites W2043521254 @default.
• W2049958615 cites W2048846997 @default.
• W2049958615 cites W2052818916 @default.
• W2049958615 cites W2053611532 @default.
• W2049958615 cites W2060281448 @default.
• W2049958615 cites W2072708027 @default.
• W2049958615 cites W2078275307 @default.
• W2049958615 cites W2086973301 @default.
• W2049958615 cites W2089333797 @default.
• W2049958615 cites W2104124112 @default.
• W2049958615 cites W2139666587 @default.
• W2049958615 cites W2152887853 @default.
• W2049958615 cites W2156889680 @default.
• W2049958615 cites W4206356470 @default.
• W2049958615 cites W4229510242 @default.
• W2049958615 doi "https://doi.org/10.3851/imp2291" @default.
• W2049958615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22875654" @default.
• W2049958615 hasPublicationYear "2012" @default.
• W2049958615 type Work @default.
• W2049958615 sameAs 2049958615 @default.
• W2049958615 citedByCount "12" @default.
• W2049958615 countsByYear W20499586152014 @default.
• W2049958615 countsByYear W20499586152016 @default.
• W2049958615 countsByYear W20499586152018 @default.
• W2049958615 countsByYear W20499586152021 @default.
• W2049958615 countsByYear W20499586152022 @default.
• W2049958615 countsByYear W20499586152023 @default.
• W2049958615 crossrefType "journal-article" @default.
• W2049958615 hasAuthorship W2049958615A5001344640 @default.
• W2049958615 hasAuthorship W2049958615A5007357880 @default.
• W2049958615 hasAuthorship W2049958615A5045849567 @default.
• W2049958615 hasAuthorship W2049958615A5054474510 @default.
• W2049958615 hasAuthorship W2049958615A5058989459 @default.
• W2049958615 hasAuthorship W2049958615A5065970650 @default.
• W2049958615 hasAuthorship W2049958615A5076097951 @default.
• W2049958615 hasConcept C103038307 @default.
• W2049958615 hasConcept C140704245 @default.
• W2049958615 hasConcept C153911025 @default.
• W2049958615 hasConcept C159047783 @default.
• W2049958615 hasConcept C175656101 @default.
• W2049958615 hasConcept C2522874641 @default.
• W2049958615 hasConcept C2781196997 @default.
• W2049958615 hasConcept C54355233 @default.
• W2049958615 hasConcept C58475186 @default.
• W2049958615 hasConcept C81885089 @default.
• W2049958615 hasConcept C86803240 @default.
• W2049958615 hasConcept C89138240 @default.
• W2049958615 hasConcept C92488253 @default.
• W2049958615 hasConceptScore W2049958615C103038307 @default.
• W2049958615 hasConceptScore W2049958615C140704245 @default.
• W2049958615 hasConceptScore W2049958615C153911025 @default.
• W2049958615 hasConceptScore W2049958615C159047783 @default.
• W2049958615 hasConceptScore W2049958615C175656101 @default.
• W2049958615 hasConceptScore W2049958615C2522874641 @default.
• W2049958615 hasConceptScore W2049958615C2781196997 @default.
• W2049958615 hasConceptScore W2049958615C54355233 @default.
• W2049958615 hasConceptScore W2049958615C58475186 @default.
• W2049958615 hasConceptScore W2049958615C81885089 @default.
• W2049958615 hasConceptScore W2049958615C86803240 @default.
• W2049958615 hasConceptScore W2049958615C89138240 @default.
• W2049958615 hasConceptScore W2049958615C92488253 @default.
• W2049958615 hasIssue "7" @default.
• W2049958615 hasLocation W20499586151 @default.
• W2049958615 hasLocation W20499586152 @default.
• W2049958615 hasOpenAccess W2049958615 @default.
• W2049958615 hasPrimaryLocation W20499586151 @default.
• W2049958615 hasRelatedWork W1551760256 @default.
• W2049958615 hasRelatedWork W1912738419 @default.
• W2049958615 hasRelatedWork W2005691864 @default.
• W2049958615 hasRelatedWork W2049958615 @default.
• W2049958615 hasRelatedWork W2055706740 @default.
• W2049958615 hasRelatedWork W2060755007 @default.

• next