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- W2049968319 abstract "To examine how nicotine increases left ventricular stroke volume despite a concomitant rise in aortic blood pressure, the effects of nicotine and aortic constriction were compared in 11 anesthetized open-chest dogs whose myocardial dimensions were measured by ultrasound elements sewn into the ventricular wall. Stroke volume was increased by 22 ± 7% (mean ± S.E.M.; P < 0.02) during infusion of nicotine (20–25 μg · kg−1 · min−1). Simultaneously, left ventricular end-diastolic pressure (LVEDP) and end-diastolic myocardial chord length (EDMCL) increased (P < 0.005), as did systolic myocardial shortening (MS) (P < 0.01) and myocardial contractility (P < 0.001). Left ventricular systolic pressure (LVSP) rose by 37 ± 5 mm Hg (P < 0.001) during the infusion of nicotine. When a similar increase in LVSP was effected by aortic constriction, stroke volume was reduced by 12 ± 4% (P < 0.01), and LVEDP and EDMCL increased significantly more than during the nicotine infusion, whereas MS and myocardial contractility remai..." @default.
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- W2049968319 title "Cardiac Effects of Nicotine in Dogs" @default.
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- W2049968319 doi "https://doi.org/10.1080/00365517409082483" @default.
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