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- W2049968961 endingPage "1398" @default.
- W2049968961 startingPage "1383" @default.
- W2049968961 abstract "Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients for which therapy fails while some patients experience severe toxicity. In the last few years, several pharmacogenetic studies have been performed to search for markers of outcome and toxicity in pediatric ALL. However, to date, TPMT is the only pharmacogenetic marker in ALL with clinical guidelines for drug dosing. In this article, we will provide an overview of the most important findings carried out in pharmacogenetics for pediatric ALL, such as the interest drawn by methotrexate transporters in the context of methotrexate treatment. Even if most of the studies are centered on coding genes, we will also point to new approaches focusing on noncoding regions and epigenetic variation that could be interesting for consideration in the near future." @default.
- W2049968961 created "2016-06-24" @default.
- W2049968961 creator A5034521218 @default.
- W2049968961 creator A5074145126 @default.
- W2049968961 creator A5076226937 @default.
- W2049968961 creator A5077551755 @default.
- W2049968961 creator A5078681789 @default.
- W2049968961 creator A5089473155 @default.
- W2049968961 date "2014-07-01" @default.
- W2049968961 modified "2023-10-18" @default.
- W2049968961 title "Pharmacogenetics of childhood acute lymphoblastic leukemia" @default.
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