FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049969271> ?p ?o ?g. }

• W2049969271 endingPage "88" @default.
• W2049969271 startingPage "83" @default.
• W2049969271 abstract "Osteoporosis is a serious complication of kidney transplantation. Various factors have been postulated to contribute to posttransplant bone loss, among them treatment with corticosteroids, the use of cyclosporine and cyclosporine-like agents, and persistent hyperparathyroidism. In a previous cross-sectional study of long-term renal transplant recipients, we observed that osteoporosis or osteopenia was present in 88% of patients. Because biochemical markers of bone formation (serum osteocalcin) and bone resorption (urine pyridinoline, PYD, and deoxypyridinoline, DPD) were elevated in the majority of study subjects, we hypothesized that elevated rates of bone-turnover contribute to posttransplant bone loss in long-term renal transplant patients. This study was performed to examine this hypothesis.The study population was composed of 62 patients who were more than 1-year postrenal transplantation and who had preserved renal function. They were followed prospectively for 1 year. Biochemical markers of bone-turnover were measured at study entry, and patients were classified as having high bone-turnover based on elevated urinary levels of at least one marker of bone resorption (i.e., PYD or DPD) and/or serum osteocalcin (group 1). If none of these were present, they were classified as having normal bone-turnover (group 2). Bone mineral density (BMD) was measured by dual energy x-ray absorptiometry (DEXA) at time of entry into the study and again after 1 year of follow-up. The changes in BMD at the lumbar spine, hip, and wrist over the period of the study were compared between the high and normal bone-turnover groups.Forty-three patients (69%) were classified as having high bone-turnover (Group 1), and 19 patients (31%) were classified as having normal bone-turnover (Group 2). There was a statistically significant difference in change in BMD between the two groups at the lumbar spine (-1.11+/-0.42%, high bone-turnover, vs. 0.64+/-0.54%, normal bone-turnover; P=0.02) and the hip (-0.69+/-0.38%, high bone-turnover, vs. 1.36+/-0.66%, normal bone-turnover; P=0.006). Whereas group 2 had stable bone mass, group 1 exhibited bone loss at these skeletal sites.Our results indicate that bone loss is greater in renal transplant recipients with elevated biochemical markers of bone-turnover, suggesting that these markers may be useful in identifying patients at risk for continued bone loss. These data support the hypothesis that continued bone loss in long-term renal transplant recipients is associated with high bone-turnover. If accelerated bone resorption does play a role in posttransplant bone loss, this would provide a strong rationale for use of antiresorptive therapy for the prevention and treatment of this complication." @default.
• W2049969271 created "2016-06-24" @default.
• W2049969271 creator A5001727280 @default.
• W2049969271 creator A5002363138 @default.
• W2049969271 creator A5016281544 @default.
• W2049969271 creator A5023473082 @default.
• W2049969271 creator A5030559488 @default.
• W2049969271 creator A5053454973 @default.
• W2049969271 creator A5055641686 @default.
• W2049969271 creator A5063497362 @default.
• W2049969271 creator A5069142714 @default.
• W2049969271 creator A5069537700 @default.
• W2049969271 creator A5075013519 @default.
• W2049969271 creator A5085820214 @default.
• W2049969271 date "2001-07-01" @default.
• W2049969271 modified "2023-10-18" @default.
• W2049969271 title "PARAMETERS OF HIGH BONE-TURNOVER PREDICT BONE LOSS IN RENAL TRANSPLANT PATIENTS: A LONGITUDINAL STUDY1,2" @default.
• W2049969271 cites W1258321623 @default.
• W2049969271 cites W1965354004 @default.
• W2049969271 cites W1967976190 @default.
• W2049969271 cites W1987347738 @default.
• W2049969271 cites W1998316939 @default.
• W2049969271 cites W2005258782 @default.
• W2049969271 cites W2006753445 @default.
• W2049969271 cites W2025769734 @default.
• W2049969271 cites W2029669003 @default.
• W2049969271 cites W2040645421 @default.
• W2049969271 cites W2051391628 @default.
• W2049969271 cites W2056610677 @default.
• W2049969271 cites W2059099737 @default.
• W2049969271 cites W2074181554 @default.
• W2049969271 cites W2082392098 @default.
• W2049969271 cites W2088964415 @default.
• W2049969271 cites W2117033916 @default.
• W2049969271 cites W2137885923 @default.
• W2049969271 cites W2313649741 @default.
• W2049969271 doi "https://doi.org/10.1097/00007890-200107150-00017" @default.
• W2049969271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11468539" @default.
• W2049969271 hasPublicationYear "2001" @default.
• W2049969271 type Work @default.
• W2049969271 sameAs 2049969271 @default.
• W2049969271 citedByCount "46" @default.
• W2049969271 countsByYear W20499692712012 @default.
• W2049969271 countsByYear W20499692712013 @default.
• W2049969271 countsByYear W20499692712014 @default.
• W2049969271 countsByYear W20499692712015 @default.
• W2049969271 countsByYear W20499692712017 @default.
• W2049969271 countsByYear W20499692712018 @default.
• W2049969271 countsByYear W20499692712021 @default.
• W2049969271 countsByYear W20499692712022 @default.
• W2049969271 crossrefType "journal-article" @default.
• W2049969271 hasAuthorship W2049969271A5001727280 @default.
• W2049969271 hasAuthorship W2049969271A5002363138 @default.
• W2049969271 hasAuthorship W2049969271A5016281544 @default.
• W2049969271 hasAuthorship W2049969271A5023473082 @default.
• W2049969271 hasAuthorship W2049969271A5030559488 @default.
• W2049969271 hasAuthorship W2049969271A5053454973 @default.
• W2049969271 hasAuthorship W2049969271A5055641686 @default.
• W2049969271 hasAuthorship W2049969271A5063497362 @default.
• W2049969271 hasAuthorship W2049969271A5069142714 @default.
• W2049969271 hasAuthorship W2049969271A5069537700 @default.
• W2049969271 hasAuthorship W2049969271A5075013519 @default.
• W2049969271 hasAuthorship W2049969271A5085820214 @default.
• W2049969271 hasConcept C126322002 @default.
• W2049969271 hasConcept C126894567 @default.
• W2049969271 hasConcept C131075544 @default.
• W2049969271 hasConcept C134018914 @default.
• W2049969271 hasConcept C160160445 @default.
• W2049969271 hasConcept C170033053 @default.
• W2049969271 hasConcept C181199279 @default.
• W2049969271 hasConcept C185592680 @default.
• W2049969271 hasConcept C2776541429 @default.
• W2049969271 hasConcept C2776886416 @default.
• W2049969271 hasConcept C2777083390 @default.
• W2049969271 hasConcept C2778588143 @default.
• W2049969271 hasConcept C2780303639 @default.
• W2049969271 hasConcept C2780787237 @default.
• W2049969271 hasConcept C2908647359 @default.
• W2049969271 hasConcept C2911091166 @default.
• W2049969271 hasConcept C55493867 @default.
• W2049969271 hasConcept C673006 @default.
• W2049969271 hasConcept C71924100 @default.
• W2049969271 hasConcept C99454951 @default.
• W2049969271 hasConceptScore W2049969271C126322002 @default.
• W2049969271 hasConceptScore W2049969271C126894567 @default.
• W2049969271 hasConceptScore W2049969271C131075544 @default.
• W2049969271 hasConceptScore W2049969271C134018914 @default.
• W2049969271 hasConceptScore W2049969271C160160445 @default.
• W2049969271 hasConceptScore W2049969271C170033053 @default.
• W2049969271 hasConceptScore W2049969271C181199279 @default.
• W2049969271 hasConceptScore W2049969271C185592680 @default.
• W2049969271 hasConceptScore W2049969271C2776541429 @default.
• W2049969271 hasConceptScore W2049969271C2776886416 @default.
• W2049969271 hasConceptScore W2049969271C2777083390 @default.
• W2049969271 hasConceptScore W2049969271C2778588143 @default.
• W2049969271 hasConceptScore W2049969271C2780303639 @default.
• W2049969271 hasConceptScore W2049969271C2780787237 @default.
• W2049969271 hasConceptScore W2049969271C2908647359 @default.

• next