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• W2049970553 abstract "Mannich bases of gatifloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. Their chemical structures have been confirmed by means of their IR, 1H-NMR data and by elemental analysis. The compounds were tested in-vitro against a panel of 58 human tumour cell lines derived from nine neoplastic diseases. Among them compound 1-cyclopropyl-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-7[[N4-(3'-sulphadoximino)-1'-(5-bromoisatinyl) methyl]-3-methyl N1-piperazinyl]-3-quinoline carboxylic acid (6) emerged as a potent anticancer agent being more active than standard DNA topoisomerase II inhibitor, etoposide against 30 cancer cell lines." @default.
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• W2049970553 date "2005-10-01" @default.
• W2049970553 modified "2023-10-16" @default.
• W2049970553 title "Synthesis and in-vitro cytotoxicity evaluation of Gatifloxacin Mannich bases" @default.
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• W2049970553 doi "https://doi.org/10.1016/j.biopha.2005.06.006" @default.
• W2049970553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16263236" @default.
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