FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049975736> ?p ?o ?g. }

• W2049975736 endingPage "e61132" @default.
• W2049975736 startingPage "e61132" @default.
• W2049975736 abstract "Our previous studies have demonstrated that PMS1077, a platelet-activating factor (PAF) antagonist, could induce apoptosis of Raji cells. However, the mechanism of action has not yet been determined. The nuclear transcription factor-kappa B (NF-κB) signaling pathway plays a critical role in tumor cell survival, proliferation, invasion, metastasis, and angiogenesis, so we determined the effects of PMS1077 and its structural analogs on tumor necrosis factor-α (TNF-α) induced activation of NF-κB signaling. In this study, we found that PMS1077 inhibited TNF-α induced expression of the NF-κB regulated reporter gene in a dose dependent manner. Western blot assay indicated that PMS1077 suppressed the TNF-α induced inhibitor of κB-α (IκB-α) phosphorylation, IκB-α degradation, and p65 phosphorylation. PMS1077 consistently blocked TNF-α induced p65 nuclear translocation as demonstrated in the immunofluorescence assay used. Docking studies by molecular modeling predicted that PMS1077 might interact directly with the IκB kinase-β (IKK-β) subunit. These results suggested that PMS1077 might suppress the activation of NF-κB by targeting IKK-β involved in the NF-κB signaling pathway. Finally, we showed that PMS1077 sensitized cells to TNF-α induced apoptosis by suppressing the expression of NF-κB regulated anti-apoptotic genes. Our results reveal a novel function of PMS1077 on the NF-κB signaling pathway and imply that PMS1077 can be considered as an anti-tumor lead compound." @default.
• W2049975736 created "2016-06-24" @default.
• W2049975736 creator A5017713701 @default.
• W2049975736 creator A5024986501 @default.
• W2049975736 creator A5038161005 @default.
• W2049975736 creator A5040747953 @default.
• W2049975736 creator A5042385205 @default.
• W2049975736 creator A5048379858 @default.
• W2049975736 creator A5052788634 @default.
• W2049975736 creator A5053002486 @default.
• W2049975736 creator A5056203159 @default.
• W2049975736 creator A5065243448 @default.
• W2049975736 creator A5074905304 @default.
• W2049975736 creator A5076872000 @default.
• W2049975736 date "2013-04-09" @default.
• W2049975736 modified "2023-09-29" @default.
• W2049975736 title "PMS1077 Sensitizes TNF-α Induced Apoptosis in Human Prostate Cancer Cells by Blocking NF-κB Signaling Pathway" @default.
• W2049975736 cites W1205185852 @default.
• W2049975736 cites W1534551308 @default.
• W2049975736 cites W1971669592 @default.
• W2049975736 cites W1973862406 @default.
• W2049975736 cites W1989638707 @default.
• W2049975736 cites W1992947643 @default.
• W2049975736 cites W1993285168 @default.
• W2049975736 cites W1996217096 @default.
• W2049975736 cites W2000387935 @default.
• W2049975736 cites W2003980838 @default.
• W2049975736 cites W2003982318 @default.
• W2049975736 cites W2004779806 @default.
• W2049975736 cites W2006617140 @default.
• W2049975736 cites W2013845759 @default.
• W2049975736 cites W2022218113 @default.
• W2049975736 cites W2028046413 @default.
• W2049975736 cites W2028382049 @default.
• W2049975736 cites W2046160463 @default.
• W2049975736 cites W2050216706 @default.
• W2049975736 cites W2050608244 @default.
• W2049975736 cites W2051994734 @default.
• W2049975736 cites W2063126618 @default.
• W2049975736 cites W2063132475 @default.
• W2049975736 cites W2063609334 @default.
• W2049975736 cites W2071941388 @default.
• W2049975736 cites W2074473216 @default.
• W2049975736 cites W2074536442 @default.
• W2049975736 cites W2075172606 @default.
• W2049975736 cites W2086189875 @default.
• W2049975736 cites W2092460415 @default.
• W2049975736 cites W2105668062 @default.
• W2049975736 cites W2117687785 @default.
• W2049975736 cites W2156066970 @default.
• W2049975736 cites W2162250897 @default.
• W2049975736 cites W2316386966 @default.
• W2049975736 cites W2950729648 @default.
• W2049975736 doi "https://doi.org/10.1371/journal.pone.0061132" @default.
• W2049975736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3621893" @default.
• W2049975736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23593410" @default.
• W2049975736 hasPublicationYear "2013" @default.
• W2049975736 type Work @default.
• W2049975736 sameAs 2049975736 @default.
• W2049975736 citedByCount "13" @default.
• W2049975736 countsByYear W20499757362014 @default.
• W2049975736 countsByYear W20499757362015 @default.
• W2049975736 countsByYear W20499757362016 @default.
• W2049975736 countsByYear W20499757362017 @default.
• W2049975736 countsByYear W20499757362018 @default.
• W2049975736 countsByYear W20499757362019 @default.
• W2049975736 countsByYear W20499757362020 @default.
• W2049975736 countsByYear W20499757362021 @default.
• W2049975736 countsByYear W20499757362022 @default.
• W2049975736 crossrefType "journal-article" @default.
• W2049975736 hasAuthorship W2049975736A5017713701 @default.
• W2049975736 hasAuthorship W2049975736A5024986501 @default.
• W2049975736 hasAuthorship W2049975736A5038161005 @default.
• W2049975736 hasAuthorship W2049975736A5040747953 @default.
• W2049975736 hasAuthorship W2049975736A5042385205 @default.
• W2049975736 hasAuthorship W2049975736A5048379858 @default.
• W2049975736 hasAuthorship W2049975736A5052788634 @default.
• W2049975736 hasAuthorship W2049975736A5053002486 @default.
• W2049975736 hasAuthorship W2049975736A5056203159 @default.
• W2049975736 hasAuthorship W2049975736A5065243448 @default.
• W2049975736 hasAuthorship W2049975736A5074905304 @default.
• W2049975736 hasAuthorship W2049975736A5076872000 @default.
• W2049975736 hasBestOaLocation W20499757361 @default.
• W2049975736 hasConcept C100175707 @default.
• W2049975736 hasConcept C104317684 @default.
• W2049975736 hasConcept C11960822 @default.
• W2049975736 hasConcept C123233396 @default.
• W2049975736 hasConcept C123298856 @default.
• W2049975736 hasConcept C153911025 @default.
• W2049975736 hasConcept C17991360 @default.
• W2049975736 hasConcept C185592680 @default.
• W2049975736 hasConcept C190283241 @default.
• W2049975736 hasConcept C203014093 @default.
• W2049975736 hasConcept C2777730290 @default.
• W2049975736 hasConcept C2779730028 @default.
• W2049975736 hasConcept C502942594 @default.
• W2049975736 hasConcept C55493867 @default.
• W2049975736 hasConcept C62478195 @default.

• next