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- W2049983574 abstract "Abstract Background: Current data are conflicting about the influence of gender on cystatin C concentrations. The goal of this study was to determine the reference interval for serum cystatin C in normal Brazilian subjects, taking into account the influence of gender. Methods: Ninety-seven healthy volunteers, aged 18–70 years, 44% male, had glomerular filtration rate (GFR) measured using a 51 Cr-EDTA method and estimated with the Modification of Diet in Renal Disease (MDRD) study equation. Serum cystatin C was measured using a turbidimetric method, and creatinine by the Jaffe method. Results: Mean serum cystatin C was not significantly different between males and females, 0.62±0.12 vs. 0.65±0.12 mg/L, respectively (p=0.26). However, median serum creatinine was significantly higher in men [97 (80–115) vs. 80 (53–88) μmol/L; p=0.0001]. There were also no significant differences between genders with respect to GFR measured using 51 Cr-EDTA (103±14 for males and 106±19 mL/min/1.73 m 2 for females, p=0.47), and estimated with the MDRD equation (86±12 vs. 83±16 mL/min/1.73 m 2 , respectively, p=0.24). Conclusions: There was no effect of gender on serum cystatin C, as well as on measured and estimated GFR. Clin Chem Lab Med 2010;48:405–8." @default.
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- W2049983574 date "2009-12-18" @default.
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- W2049983574 title "Gender does not influence cystatin C concentrations in healthy volunteers" @default.
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- W2049983574 doi "https://doi.org/10.1515/cclm.2010.068" @default.
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