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• W2049984340 abstract "Objective To investigate the features of synovial stromal cells established from patients with rheumatoid arthritis (RA), and to define these cells as nurse cells. Methods Synovial nurse-like stromal cell lines (RA-SNCs) were established from patients with RA. These cell lines were examined for morphology, pseudoemperipolesis activity, cell surface markers, and cytokine production. The interaction between these RA-SNCs and a synovial tissue B cell clone was also examined. Results RA-SNCs had nurse cell activity. They spontaneously produced interleukin-6 (IL-6), IL-8, granulocyte colony-stimulating factor, and granulocyte–macrophage colony-stimulating factor. Furthermore, they produced IL-1β and tumor necrosis factor α and expressed higher levels of the other cytokines after coculture with the B cell clone. Proliferation and Ig production by the B cell clone were dependent on direct contact with RA-SNCs. Conclusion These results indicate that the RA-SNCs were nurse cells. The findings suggest that RA-SNCs may play an important role in the pathogenesis of RA by producing large amounts of cytokines and maintaining infiltrating lymphocytes." @default.
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• W2049984340 date "1999-02-01" @default.
• W2049984340 modified "2023-09-23" @default.
• W2049984340 title "Establishment and characterization of nurse cell-like stromal cell lines from synovial tissues of patients with rheumatoid arthritis" @default.
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• W2049984340 doi "https://doi.org/10.1002/1529-0131(199902)42:2<221::aid-anr3>3.0.co;2-n" @default.
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