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• W2050027900 startingPage "82" @default.
• W2050027900 abstract "The changes induced in the small intestine of the rat by infection with Nippostrongylus brasiliensis have been studied, both in single and multiple infections. The effect of diet on the host's response to infection by N. brasiliensis was studied by maintaining rats on normal diet (R.C.86) and on low protein diet (L.P.D.) under otherwise similar conditions of temperature and environment. Rats maintained on normal diet eliminated their worm burden after 12 days. Rats maintained on low protein diet did not eliminate their worm burden until after 23 days. Rats similarly maintained on each of these two diets received at intervals three consecutive infections of N. brasiliensis followed by a challenge infection in order to discover whether the different diets altered the host's ability to develop immunity. Rats maintained on normal diet developed a strong immunity following repeated infections. Rats maintained on low protein diet developed a very weak immunity following repeated infections. The small intestines from rats maintained on normal and low protein diets, both infected and uninfected, were examined histologically for changes in the numbers of mast cells and eosinophils present. Rats on the normal diet showed similar mast cell changes to those on the low protein diet, although the changes were more violent in the latter ones. By contrast, the eosinophil response in normal rats was more pronounced than that in the low protein diet rats. The histamine content of the small intestine was estimated in rats receiving the two different diets. Rats on the normal diet showed less pronounced changes in histamine concentrations than did those on the low protein diet. The theory that eosinophils act as antagonists to histamine is supported. Evidence is produced which suggests that mast cells play a part in cellular reactions to parasitic infection." @default.
• W2050027900 created "2016-06-24" @default.
• W2050027900 creator A5043706519 @default.
• W2050027900 date "1962-01-01" @default.
• W2050027900 modified "2023-10-17" @default.
• W2050027900 title "Mast cell, eosinophil and histamine levels in Nippostrongylus brasiliensis infected rats" @default.
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• W2050027900 doi "https://doi.org/10.1016/s0014-4894(62)80002-2" @default.
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