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- W2050050016 abstract "The SNARE proteins VAMP/synaptobrevin, SNAP-25 and Syntaxin are core components of the apparatus that mediates neurotransmitter release. They form a heterotrimeric complex and an undetermined number of SNARE complexes assemble to form a super-complex. Here, we present a radial model of this nanomachine, derived from experiments performed with botulinum neurotoxins, which led to the identification of one arginine in SNAP-25 and one aspartate in Syntaxin (R206 and D253 in Drosophila melanogaster). These residues are highly conserved and predicted to play a major role in the protein-protein interactions among SNARE complexes by forming an ionic couple. Accordingly, we generated transgenic Drosophila lines expressing SNAREs mutated in these residues and performed an electrophysiological analysis of their neuromuscular junctions. Our results indicate that SNAP-25-R206 and Syntaxin-D253 play a major role in neuroexocytosis and support a radial assembly of several SNARE complexes interacting via the ionic couple formed by these two residues." @default.
- W2050050016 created "2016-06-24" @default.
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- W2050050016 date "2013-01-01" @default.
- W2050050016 modified "2023-10-07" @default.
- W2050050016 title "Evidence for a radial SNARE super-complex mediating neurotransmitter release at the <i>Drosophila</i> neuromuscular junction" @default.
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- W2050050016 cites W1916164999 @default.
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- W2050050016 cites W1970603179 @default.
- W2050050016 cites W1974537340 @default.
- W2050050016 cites W1975642381 @default.
- W2050050016 cites W1976479871 @default.
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- W2050050016 cites W1982630258 @default.
- W2050050016 cites W1985842673 @default.
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- W2050050016 cites W2032674098 @default.
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- W2050050016 doi "https://doi.org/10.1242/jcs.123802" @default.
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