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• W2050060476 abstract "A complex of the Adenovirus (Ad) early region 1b 55-kDa protein (E1b-55kDa) and the early region 4 ORF6 34-kDa protein (E4-34kDa) promotes viral late RNA accumulation in the cytoplasm while inhibiting the transport of most newly synthesized cellular mRNA. The E4 ORF3 11-kDa protein (E4-11kDa) functionally compensates for at least some of the activities of this complex. We find that the same large central region of E4-34kDa that is required for proteasome-mediated degradation of p53 (J. Virol. 75, (2001) 699–709) is also required to promote viral late gene expression in a complementation assay. E4-34kDa does not promote late gene expression in complementation assays performed in the presence of proteasome inhibitors. A proteasome inhibitor also dramatically reduced late gene expression by a virus that lacks the E4-11kDa gene and therefore relies on E4-34kDa for late gene expression. Our results suggest that E4-34kDa activity in promoting late gene expression depends on the proteasome." @default.
• W2050060476 created "2016-06-24" @default.
• W2050060476 creator A5027818001 @default.
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• W2050060476 date "2003-10-01" @default.
• W2050060476 modified "2023-09-27" @default.
• W2050060476 title "Adenovirus E4-34kDa requires active proteasomes to promote late gene expression" @default.
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• W2050060476 doi "https://doi.org/10.1016/s0042-6822(03)00527-0" @default.
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