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- W2050062705 abstract "Neuron-derived orphan receptor-1 (NOR-1) is a novel member of the Nur77/NGFI-B subfamily within the nuclear receptor superfamily. Recently, several proteins closely related to NOR-1 have been described. To elucidate the relationships between NOR-1 and these closely related proteins, we analyzed the human NOR-1 gene and its transcripts by molecular cloning. We identified two variant NOR-1 transcripts in human skeletal muscles. One variant has a different 5′-untranslated region, and the other lacks C-terminal amino acid sequences corresponding to the putative ligand binding domain. These variant sequences share the common exon–intron boundary with NOR-1 mRNA, suggesting that they were generated from a single gene by alternative splicing, with the divergent points conserved between the rat and human. We also examined the promoter activities of the 5′-flanking regions of the two NOR-1 transcripts (NOR-1α and NOR-1β mRNAs) by luciferase gene transfection. We demonstrated that the 5′-flanking region of the previously described NOR-1 gene, which has characteristics of a promoter found in housekeeping genes, showed potent promoter activity although the promoter for NOR-1β mRNAs could not be determined." @default.
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- W2050062705 date "1998-04-01" @default.
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- W2050062705 title "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA" @default.
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- W2050062705 doi "https://doi.org/10.1016/s0378-1119(98)00095-x" @default.
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