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• W2050067576 abstract "Aims To study the contribution of epidermal growth factor receptor variant III (EGFRvIII) to glioblastoma multiforme (GBM) stemness and gefitinib resistance. Methods CD133+ and CD133− cells were separated from EGFRvIII+ clinical specimens of three patients with newly diagnosed GBM. Then, RT-PCR was performed to evaluate EGFRvIII and EGFR expression in CD133+ and CD133− cells. The tumorigenicity and stemness of CD133+ cells was verified by intracranial implantation of 5 × 103 cells into immunodeficient NOD/SCID mice. Finally, cells were evaluated for their sensitivity to EGFR tyrosine kinase inhibition by gefitinib. Results RT-PCR results showed that the sorted CD133+ cells expressed EGFRvIII exclusively, while the CD133− cells expressed both EGFRvIII and EGFR. At 6–8 weeks postimplantation, CD133+/EGFRvIII+/EGFR− cells formed intracranial tumors. Cell counting kit-8 results showed that the IC50 values of the three isolated EGFRvIII+ cell lines treated with gefitinib were 14.44, 16.00, and 14.66 μM, respectively, whereas the IC50 value of an isolated EGFRvIII− cell line was 8.57 μM. Conclusions EGFRvIII contributes to the stemness of cancer stem cells through coexpression with CD133 in GBMs. Furthermore, CD133+/EGFRvIII+/EGFR− cells have the ability to initiate tumor formation and may contribute to gefitinib resistance." @default.
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• W2050067576 date "2013-04-10" @default.
• W2050067576 modified "2023-10-17" @default.
• W2050067576 title "A Minority Subpopulation of CD133⁺/EGFRvIII⁺/EGFR⁻Cells Acquires Stemness and Contributes to Gefitinib Resistance" @default.
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• W2050067576 doi "https://doi.org/10.1111/cns.12092" @default.
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