FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050086011> ?p ?o ?g. }

• W2050086011 endingPage "1542" @default.
• W2050086011 startingPage "1536" @default.
• W2050086011 abstract "Acute respiratory distress syndrome (ARDS) is a major cause of morbidity and mortality in critically ill patients. The associated ventilation/perfusion mismatch and pulmonary hypertension are amenable to treatment with inhaled nitric oxide (NO) gas. Compounds formed by reacting NO with various nucleophiles (NONOates) release NO spontaneously and induce vasodilation. Intratracheally administered NONOates result in selective reduction in pulmonary hypertension. We hypothesized that a nebulized NONOate would improve oxygenation and reduce pulmonary vascular resistance in oleic acid-induced acute lung injury and pulmonary hypertension. Pigs underwent catheterization of the pulmonary artery, left atrium, and right atrium, and a flow probe was positioned around the pulmonary artery. Acute lung injury and pulmonary hypertension were induced with intravenous oleic acid. Animals were randomly assigned to receive either nebulized saline or the NONOate 2-(dimethylamino)ethylputreanine/NO (DMAEP/NO). Hemodynamic, gas exchange, pulmonary function, methemoglobin, and nitrite/nitrate measurements were obtained for 60 min. Animals in the DMAEP/NO group had improvement in PaO2 as compared with control animals (from 139 ± 19 mm Hg to 180 ± 19 mm Hg in the DMAEP/NO group [n = 6]; and from 144 ± 6 mm Hg to 150 ± 9 mm Hg in the saline group [n = 6], p < 0.05). After aerosol treatment, animals in the DMAEP/NO group had a greater reduction in pulmonary vascular resistance index (PVRI) than did control animals (from 81 ± 17 dyne · s/cm5/kg to 34 ± 8 dyne · s/cm5/kg; and from 104 ± 16 dyne · s/cm5/kg to 64 ± 11 dyne · sec/cm5/ kg in the saline group at 60 min, p < 0.05). There were no differences between the groups in systemic vascular resistance index (SVRI), cardiac index (CI), methemoglobin, nitrite/nitrate, or lung pathology scores. We conclude that DMAEP/NO improves oxygenation and has selective pulmonary vasodilating properties without causing significant systemic toxicity in this porcine model of acute lung injury." @default.
• W2050086011 created "2016-06-24" @default.
• W2050086011 creator A5001745938 @default.
• W2050086011 creator A5011283939 @default.
• W2050086011 creator A5023924862 @default.
• W2050086011 creator A5069014811 @default.
• W2050086011 creator A5080253342 @default.
• W2050086011 date "1998-11-01" @default.
• W2050086011 modified "2023-10-15" @default.
• W2050086011 title "Aerosolized Soluble Nitric Oxide Donor Improves Oxygenation and Pulmonary Hypertension in Acute Lung Injury" @default.
• W2050086011 cites W1808162238 @default.
• W2050086011 cites W1821918060 @default.
• W2050086011 cites W1927797304 @default.
• W2050086011 cites W1971330063 @default.
• W2050086011 cites W1974939571 @default.
• W2050086011 cites W1977692928 @default.
• W2050086011 cites W1981464436 @default.
• W2050086011 cites W1983969834 @default.
• W2050086011 cites W1986136320 @default.
• W2050086011 cites W1990802251 @default.
• W2050086011 cites W1998879311 @default.
• W2050086011 cites W2001837257 @default.
• W2050086011 cites W2004920951 @default.
• W2050086011 cites W2008427562 @default.
• W2050086011 cites W2011306732 @default.
• W2050086011 cites W2026389747 @default.
• W2050086011 cites W2029478671 @default.
• W2050086011 cites W2030491466 @default.
• W2050086011 cites W2031212351 @default.
• W2050086011 cites W2033501945 @default.
• W2050086011 cites W2035053320 @default.
• W2050086011 cites W2039417913 @default.
• W2050086011 cites W2044106219 @default.
• W2050086011 cites W2051275330 @default.
• W2050086011 cites W2051620935 @default.
• W2050086011 cites W2052372952 @default.
• W2050086011 cites W2064344348 @default.
• W2050086011 cites W2074359940 @default.
• W2050086011 cites W2075355170 @default.
• W2050086011 cites W2079199091 @default.
• W2050086011 cites W2093216413 @default.
• W2050086011 cites W2127708759 @default.
• W2050086011 cites W2136405612 @default.
• W2050086011 cites W2171341158 @default.
• W2050086011 cites W2219040786 @default.
• W2050086011 cites W2336418757 @default.
• W2050086011 cites W2428929704 @default.
• W2050086011 cites W2952342392 @default.
• W2050086011 doi "https://doi.org/10.1164/ajrccm.158.5.9802114" @default.
• W2050086011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9817705" @default.
• W2050086011 hasPublicationYear "1998" @default.
• W2050086011 type Work @default.
• W2050086011 sameAs 2050086011 @default.
• W2050086011 citedByCount "39" @default.
• W2050086011 countsByYear W20500860112012 @default.
• W2050086011 countsByYear W20500860112013 @default.
• W2050086011 countsByYear W20500860112016 @default.
• W2050086011 countsByYear W20500860112017 @default.
• W2050086011 countsByYear W20500860112020 @default.
• W2050086011 countsByYear W20500860112022 @default.
• W2050086011 countsByYear W20500860112023 @default.
• W2050086011 crossrefType "journal-article" @default.
• W2050086011 hasAuthorship W2050086011A5001745938 @default.
• W2050086011 hasAuthorship W2050086011A5011283939 @default.
• W2050086011 hasAuthorship W2050086011A5023924862 @default.
• W2050086011 hasAuthorship W2050086011A5069014811 @default.
• W2050086011 hasAuthorship W2050086011A5080253342 @default.
• W2050086011 hasConcept C126322002 @default.
• W2050086011 hasConcept C164705383 @default.
• W2050086011 hasConcept C178853913 @default.
• W2050086011 hasConcept C2776348555 @default.
• W2050086011 hasConcept C2777714996 @default.
• W2050086011 hasConcept C2780930700 @default.
• W2050086011 hasConcept C2780940725 @default.
• W2050086011 hasConcept C42219234 @default.
• W2050086011 hasConcept C519581460 @default.
• W2050086011 hasConcept C58245268 @default.
• W2050086011 hasConcept C70289976 @default.
• W2050086011 hasConcept C71924100 @default.
• W2050086011 hasConceptScore W2050086011C126322002 @default.
• W2050086011 hasConceptScore W2050086011C164705383 @default.
• W2050086011 hasConceptScore W2050086011C178853913 @default.
• W2050086011 hasConceptScore W2050086011C2776348555 @default.
• W2050086011 hasConceptScore W2050086011C2777714996 @default.
• W2050086011 hasConceptScore W2050086011C2780930700 @default.
• W2050086011 hasConceptScore W2050086011C2780940725 @default.
• W2050086011 hasConceptScore W2050086011C42219234 @default.
• W2050086011 hasConceptScore W2050086011C519581460 @default.
• W2050086011 hasConceptScore W2050086011C58245268 @default.
• W2050086011 hasConceptScore W2050086011C70289976 @default.
• W2050086011 hasConceptScore W2050086011C71924100 @default.
• W2050086011 hasIssue "5" @default.
• W2050086011 hasLocation W20500860111 @default.
• W2050086011 hasLocation W20500860112 @default.
• W2050086011 hasOpenAccess W2050086011 @default.
• W2050086011 hasPrimaryLocation W20500860111 @default.
• W2050086011 hasRelatedWork W1995895914 @default.
• W2050086011 hasRelatedWork W2019924882 @default.

• next