Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050093196> ?p ?o ?g. }
- W2050093196 endingPage "e105616" @default.
- W2050093196 startingPage "e105616" @default.
- W2050093196 abstract "Development of a physiologically relevant 3D model system for cancer research and drug development is a current challenge. We have adopted a 3D culture system based on a transglutaminase-crosslinked gelatin gel (Col-Tgel) to mimic the tumor 3D microenvironment. The system has several unique advantages over other alternatives including presenting cell-matrix interaction sites from collagen-derived peptides, geometry-initiated multicellular tumor spheroids, and metabolic gradients in the tumor microenvironment. Also it provides a controllable wide spectrum of gel stiffness for mechanical signals, and technical compatibility with imaging based screening due to its transparent properties. In addition, the Col-Tgel provides a cure-in-situ delivery vehicle for tumor xenograft formation in animals enhancing tumor cell uptake rate. Overall, this distinctive 3D system could offer a platform to more accurately mimic in vivo situations to study tumor formation and progression both in vitro and in vivo." @default.
- W2050093196 created "2016-06-24" @default.
- W2050093196 creator A5005638984 @default.
- W2050093196 creator A5013824442 @default.
- W2050093196 creator A5016653092 @default.
- W2050093196 creator A5059939560 @default.
- W2050093196 creator A5090640883 @default.
- W2050093196 date "2014-08-18" @default.
- W2050093196 modified "2023-09-27" @default.
- W2050093196 title "Tumor Bioengineering Using a Transglutaminase Crosslinked Hydrogel" @default.
- W2050093196 cites W1490344207 @default.
- W2050093196 cites W1493975488 @default.
- W2050093196 cites W1578597258 @default.
- W2050093196 cites W1968577363 @default.
- W2050093196 cites W1969913468 @default.
- W2050093196 cites W1970590657 @default.
- W2050093196 cites W1971116628 @default.
- W2050093196 cites W1971801942 @default.
- W2050093196 cites W1972657134 @default.
- W2050093196 cites W1978312684 @default.
- W2050093196 cites W1979700784 @default.
- W2050093196 cites W1982447134 @default.
- W2050093196 cites W1991370659 @default.
- W2050093196 cites W1998274452 @default.
- W2050093196 cites W2005334224 @default.
- W2050093196 cites W2010251891 @default.
- W2050093196 cites W2013232318 @default.
- W2050093196 cites W2016904968 @default.
- W2050093196 cites W2019441470 @default.
- W2050093196 cites W2022038342 @default.
- W2050093196 cites W2022704235 @default.
- W2050093196 cites W2025690227 @default.
- W2050093196 cites W2026235120 @default.
- W2050093196 cites W2037728152 @default.
- W2050093196 cites W2040695321 @default.
- W2050093196 cites W2044093336 @default.
- W2050093196 cites W2045761513 @default.
- W2050093196 cites W2049623878 @default.
- W2050093196 cites W2059069305 @default.
- W2050093196 cites W2076081218 @default.
- W2050093196 cites W2077087448 @default.
- W2050093196 cites W2078930759 @default.
- W2050093196 cites W2083443762 @default.
- W2050093196 cites W2085612435 @default.
- W2050093196 cites W2099052265 @default.
- W2050093196 cites W2100454719 @default.
- W2050093196 cites W2103891889 @default.
- W2050093196 cites W2105028640 @default.
- W2050093196 cites W2109048297 @default.
- W2050093196 cites W2114229735 @default.
- W2050093196 cites W2117451680 @default.
- W2050093196 cites W2121898927 @default.
- W2050093196 cites W2122917672 @default.
- W2050093196 cites W2123232388 @default.
- W2050093196 cites W2124496728 @default.
- W2050093196 cites W2126882378 @default.
- W2050093196 cites W2131516695 @default.
- W2050093196 cites W2131928591 @default.
- W2050093196 cites W2132966617 @default.
- W2050093196 cites W2134044673 @default.
- W2050093196 cites W2135640361 @default.
- W2050093196 cites W2149672704 @default.
- W2050093196 cites W2157702919 @default.
- W2050093196 cites W2162488993 @default.
- W2050093196 cites W2163149880 @default.
- W2050093196 cites W2165285849 @default.
- W2050093196 cites W2165836181 @default.
- W2050093196 cites W2185535269 @default.
- W2050093196 cites W2783142245 @default.
- W2050093196 doi "https://doi.org/10.1371/journal.pone.0105616" @default.
- W2050093196 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136878" @default.
- W2050093196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25133673" @default.
- W2050093196 hasPublicationYear "2014" @default.
- W2050093196 type Work @default.
- W2050093196 sameAs 2050093196 @default.
- W2050093196 citedByCount "30" @default.
- W2050093196 countsByYear W20500931962015 @default.
- W2050093196 countsByYear W20500931962016 @default.
- W2050093196 countsByYear W20500931962017 @default.
- W2050093196 countsByYear W20500931962018 @default.
- W2050093196 countsByYear W20500931962019 @default.
- W2050093196 countsByYear W20500931962020 @default.
- W2050093196 countsByYear W20500931962021 @default.
- W2050093196 countsByYear W20500931962022 @default.
- W2050093196 crossrefType "journal-article" @default.
- W2050093196 hasAuthorship W2050093196A5005638984 @default.
- W2050093196 hasAuthorship W2050093196A5013824442 @default.
- W2050093196 hasAuthorship W2050093196A5016653092 @default.
- W2050093196 hasAuthorship W2050093196A5059939560 @default.
- W2050093196 hasAuthorship W2050093196A5090640883 @default.
- W2050093196 hasBestOaLocation W20500931961 @default.
- W2050093196 hasConcept C108586683 @default.
- W2050093196 hasConcept C12554922 @default.
- W2050093196 hasConcept C136229726 @default.
- W2050093196 hasConcept C1491633281 @default.
- W2050093196 hasConcept C150903083 @default.
- W2050093196 hasConcept C163688615 @default.
- W2050093196 hasConcept C171250308 @default.