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• W2050116248 startingPage "1269" @default.
• W2050116248 abstract "Around all human activity, there are zones of pollution with pesticides, heavy metals, pharmaceuticals, personal care products and the microorganisms associated with human waste streams and agriculture. This diversity of pollutants, whose concentration varies spatially and temporally, is a major challenge for monitoring. Here, we suggest that the relative abundance of the clinical class 1 integron-integrase gene, intI1, is a good proxy for pollution because: (1) intI1 is linked to genes conferring resistance to antibiotics, disinfectants and heavy metals; (2) it is found in a wide variety of pathogenic and nonpathogenic bacteria; (3) its abundance can change rapidly because its host cells can have rapid generation times and it can move between bacteria by horizontal gene transfer; and (4) a single DNA sequence variant of intI1 is now found on a wide diversity of xenogenetic elements, these being complex mosaic DNA elements fixed through the agency of human selection. Here we review the literature examining the relationship between anthropogenic impacts and the abundance of intI1, and outline an approach by which intI1 could serve as a proxy for anthropogenic pollution." @default.
• W2050116248 created "2016-06-24" @default.
• W2050116248 creator A5041807449 @default.
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• W2050116248 creator A5071894027 @default.
• W2050116248 creator A5072007160 @default.
• W2050116248 creator A5073430026 @default.
• W2050116248 date "2014-12-12" @default.
• W2050116248 modified "2023-10-09" @default.
• W2050116248 title "Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution" @default.
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