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- W2050147600 abstract "Abstract Intravenous administration of a pseudomonas endotoxin (Piromen), 0.5 μg./Kg., to normal subjects produced a significant increase in plasma growth hormone concentration (mean maximum 25.5 ± 6.0 mμg./ml.) in addition to its well known stimulation of ACTH secretion. Other metabolic effects of Piromen administration included a rapid elevation of plasma free fatty acids presumed to be secondary to epinephrine release and a slight, but significant lowering of plasma glucose concentration. In 9 hypopituitary patients, the maximum plasma growth hormone concentration observed following Piromen administration was only 1.1 mμg./ml., whereas 6 of these patients exhibited a significant rise in plasma adrenal corticoids. Thus, absence of pituitary growth hormone release was found to be a more sensitive index of decreased pituitary function than impairment of ACTH release. Four hypopituitary patients with secondary adrenal insufficiency exhibited a dichotomy between the adrenal corticoid response to Piromen and methopyrapone testing. In these patients, adrenal cortical insufficiency could be attributed to a failure of ACTH release rather than to an absolute ACTH deficiency." @default.
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- W2050147600 date "1967-01-01" @default.
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- W2050147600 title "Growth hormone releasing action of a pseudomonas endotoxin (Piromen)" @default.
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- W2050147600 doi "https://doi.org/10.1016/0026-0495(67)90159-x" @default.
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