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- W2050149466 abstract "D-ribose is cytotoxic for quiescent human lymphocytes and severely inhibits their PHA-induced proliferation at concentrations (25-50 mM) at which other simple sugars are ineffective. In order to explain these effects, DNA repair synthesis was evaluated in PHA-stimulated human lymphocytes treated with hydroxyurea and irradiated. D-ribose, in contrast to other reducing sugars, did not induce repair synthesis and therefore did not apparently damage DNA in a direct way, although it markedly inhibited gamma ray-induced repair. Taking into account that lymphocytes must rejoin physiologically-formed DNA strand breaks in order to enter the cell cycle, we suggest that D-ribose exerts its cytotoxic activity by interfering with metabolic pathways critical for the repair of DNA breaks." @default.
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- W2050149466 date "1986-07-01" @default.
- W2050149466 modified "2023-09-26" @default.
- W2050149466 title "D-ribose inhibits DNA repair synthesis in human lymphocytes" @default.
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- W2050149466 doi "https://doi.org/10.1016/s0006-291x(86)80549-6" @default.
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