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- W2050179504 abstract "Rats absorb 2,6,10,14-tetramethylhexadecane (phytane) from the intestinal tract intact into the lymph. Intestinal microbes appeared to be unable to metabolize phytane in vitro. Rats metabolized phytane to (a) a tertiary alcohol tentatively identified as 2,6,10,14-tetramethylhexadecan-2-ol, and (b) a variety of short-chain acids which were excreted in the urine. These included acetic, isobutyric, and 2-methylbutyric acids. CO2 was a very minor product, even following intravenous injection of phytane. Lipoidal intermediates in the degradation of phytane could not be detected, suggesting that the initial attack on the molecule was rate-limiting. Urinary excretion products were apparent following oral but not intravenous, intraperitoneal, or subcutaneous administration of phytane. However, the tertiary alcohol was produced following both oral and intraperitoneal administration. The syntheses of [U-14C]- and [2,3,-3H2] phytane are described." @default.
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- W2050179504 date "1974-11-04" @default.
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- W2050179504 title "Metabolism of phytane in rats" @default.
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- W2050179504 doi "https://doi.org/10.1016/0304-4165(74)90067-1" @default.
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