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- W2050182398 endingPage "386" @default.
- W2050182398 startingPage "375" @default.
- W2050182398 abstract "In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells that is characterized as a potent tumor suppressor and is modulated during various processes including epithelial-mesenchymal transition. Recent data have provided evidences for novel biological functional role of Hakai during tumor progression and other diseases. Here, we will review the knowledge that has been accumulated since Hakai discovery 10 years ago and its implication in human cancer disease. We will highlight the different signaling pathways leading to the influence on Hakai and suggest its potential usefulness as therapeutic target for cancer." @default.
- W2050182398 created "2016-06-24" @default.
- W2050182398 creator A5029081977 @default.
- W2050182398 creator A5036625532 @default.
- W2050182398 creator A5038231720 @default.
- W2050182398 creator A5050689434 @default.
- W2050182398 creator A5089591380 @default.
- W2050182398 date "2012-02-19" @default.
- W2050182398 modified "2023-10-16" @default.
- W2050182398 title "Biological influence of Hakai in cancer: a 10-year review" @default.
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