FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050183480> ?p ?o ?g. }

• W2050183480 abstract "Antibody-presenting liposomes present high interest as drug delivery systems. The association of antibodies to liposomes is usually realized by covalent coupling of IgGs or their antigen-binding fragments to lipid polar head groups by means of hetero-bifunctional crosslinkers. We present here an original platform of IgG-presenting liposomes which is based on a fusion protein between Annexin-A5 (Anx5) and the IgG-binding ZZ repeat derived from Staphylococcus aureus protein A. The Anx5ZZ fusion protein acts as a bi-functional adaptor that anchors IgGs to liposomes in a non covalent and highly versatile manner. The interactions between IgGs, Anx5ZZ and liposomes were characterized by PAGE, dynamic light scattering and fluorescence quenching assays, establishing that binding of Anx5ZZ to IgGs and of Anx5ZZ–IgG complexes to liposomes is complete with stoichiometric amounts of each species. We found that the sequence of assembly is important and that Anx5ZZ–IgG complexes need to be formed first in solution and then adsorbed to liposomes in order to avoid aggregation. The targeting capacity of Anx5ZZ–IgG-functionalized liposomes was demonstrated by electron microscopy on an ex vivo model system of atherosclerotic plaques. This study shows that the Anx5ZZ adaptor constitutes an efficient platform for functionalizing liposomes with IgGs. This platform may present potential applications in molecular imaging and drug delivery." @default.
• W2050183480 created "2016-06-24" @default.
• W2050183480 creator A5006313534 @default.
• W2050183480 creator A5026965295 @default.
• W2050183480 creator A5030163616 @default.
• W2050183480 creator A5046985587 @default.
• W2050183480 creator A5065332452 @default.
• W2050183480 creator A5071272857 @default.
• W2050183480 creator A5081172893 @default.
• W2050183480 date "2012-02-09" @default.
• W2050183480 modified "2023-10-18" @default.
• W2050183480 title "Development of a Platform of Antibody-Presenting Liposomes" @default.
• W2050183480 cites W1731655839 @default.
• W2050183480 cites W1970239046 @default.
• W2050183480 cites W1975985649 @default.
• W2050183480 cites W1978002868 @default.
• W2050183480 cites W1981487606 @default.
• W2050183480 cites W1983671192 @default.
• W2050183480 cites W1993870692 @default.
• W2050183480 cites W2003709444 @default.
• W2050183480 cites W2012619372 @default.
• W2050183480 cites W2013470095 @default.
• W2050183480 cites W2021787005 @default.
• W2050183480 cites W2029911161 @default.
• W2050183480 cites W2038686095 @default.
• W2050183480 cites W2041759339 @default.
• W2050183480 cites W2046445536 @default.
• W2050183480 cites W2050644354 @default.
• W2050183480 cites W2054889106 @default.
• W2050183480 cites W2056219144 @default.
• W2050183480 cites W2061510929 @default.
• W2050183480 cites W2061672022 @default.
• W2050183480 cites W2063223500 @default.
• W2050183480 cites W2068508373 @default.
• W2050183480 cites W2072102122 @default.
• W2050183480 cites W2103036523 @default.
• W2050183480 cites W2118878458 @default.
• W2050183480 cites W2130433105 @default.
• W2050183480 cites W2166458266 @default.
• W2050183480 cites W2228598834 @default.
• W2050183480 doi "https://doi.org/10.1007/s13758-011-0011-9" @default.
• W2050183480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22589054" @default.
• W2050183480 hasPublicationYear "2012" @default.
• W2050183480 type Work @default.
• W2050183480 sameAs 2050183480 @default.
• W2050183480 citedByCount "4" @default.
• W2050183480 countsByYear W20501834802015 @default.
• W2050183480 countsByYear W20501834802016 @default.
• W2050183480 countsByYear W20501834802022 @default.
• W2050183480 crossrefType "journal-article" @default.
• W2050183480 hasAuthorship W2050183480A5006313534 @default.
• W2050183480 hasAuthorship W2050183480A5026965295 @default.
• W2050183480 hasAuthorship W2050183480A5030163616 @default.
• W2050183480 hasAuthorship W2050183480A5046985587 @default.
• W2050183480 hasAuthorship W2050183480A5065332452 @default.
• W2050183480 hasAuthorship W2050183480A5071272857 @default.
• W2050183480 hasAuthorship W2050183480A5081172893 @default.
• W2050183480 hasBestOaLocation W20501834801 @default.
• W2050183480 hasConcept C104317684 @default.
• W2050183480 hasConcept C123894998 @default.
• W2050183480 hasConcept C12554922 @default.
• W2050183480 hasConcept C14631669 @default.
• W2050183480 hasConcept C155672457 @default.
• W2050183480 hasConcept C171250308 @default.
• W2050183480 hasConcept C178790620 @default.
• W2050183480 hasConcept C180577832 @default.
• W2050183480 hasConcept C185154212 @default.
• W2050183480 hasConcept C185592680 @default.
• W2050183480 hasConcept C192562407 @default.
• W2050183480 hasConcept C2779820397 @default.
• W2050183480 hasConcept C40767141 @default.
• W2050183480 hasConcept C55493867 @default.
• W2050183480 hasConcept C86803240 @default.
• W2050183480 hasConceptScore W2050183480C104317684 @default.
• W2050183480 hasConceptScore W2050183480C123894998 @default.
• W2050183480 hasConceptScore W2050183480C12554922 @default.
• W2050183480 hasConceptScore W2050183480C14631669 @default.
• W2050183480 hasConceptScore W2050183480C155672457 @default.
• W2050183480 hasConceptScore W2050183480C171250308 @default.
• W2050183480 hasConceptScore W2050183480C178790620 @default.
• W2050183480 hasConceptScore W2050183480C180577832 @default.
• W2050183480 hasConceptScore W2050183480C185154212 @default.
• W2050183480 hasConceptScore W2050183480C185592680 @default.
• W2050183480 hasConceptScore W2050183480C192562407 @default.
• W2050183480 hasConceptScore W2050183480C2779820397 @default.
• W2050183480 hasConceptScore W2050183480C40767141 @default.
• W2050183480 hasConceptScore W2050183480C55493867 @default.
• W2050183480 hasConceptScore W2050183480C86803240 @default.
• W2050183480 hasIssue "1" @default.
• W2050183480 hasLocation W20501834801 @default.
• W2050183480 hasLocation W20501834802 @default.
• W2050183480 hasOpenAccess W2050183480 @default.
• W2050183480 hasPrimaryLocation W20501834801 @default.
• W2050183480 hasRelatedWork W1992403166 @default.
• W2050183480 hasRelatedWork W2032881319 @default.
• W2050183480 hasRelatedWork W2033370647 @default.
• W2050183480 hasRelatedWork W2625102875 @default.
• W2050183480 hasRelatedWork W2790600185 @default.
• W2050183480 hasRelatedWork W2809599773 @default.
• W2050183480 hasRelatedWork W3026260006 @default.

• next