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- W2050190084 endingPage "187" @default.
- W2050190084 startingPage "173" @default.
- W2050190084 abstract "Ischemic postconditioning is a concept originally defined to contrast with that of ischemic preconditioning. While both preconditioning and postconditioning confer a neuroprotective effect on brain ischemia, preconditioning is a sublethal insult performed in advance of brain ischemia, and postconditioning, which conventionally refers to a series of brief occlusions and reperfusions of the blood vessels, is conducted after ischemia/reperfusion. In this article, we first briefly review the history of preconditioning, including the experimentation that initially uncovered its neuroprotective effects and later revealed its underlying mechanisms-of-action. We then discuss how preconditioning research evolved into that of postconditioning--a concept that now represents a broad range of stimuli or triggers, including delayed postconditioning, pharmacological postconditioning, remote postconditioning--and its underlying protective mechanisms involving the Akt, MAPK, PKC and K(ATP) channel cell-signaling pathways. Because the concept of postconditioning is so closely associated with that of preconditioning, and both share some common protective mechanisms, we also discuss whether a combination of preconditioning and postconditioning offers greater protection than preconditioning or postconditioning alone." @default.
- W2050190084 created "2016-06-24" @default.
- W2050190084 creator A5010178211 @default.
- W2050190084 creator A5013509380 @default.
- W2050190084 creator A5043106765 @default.
- W2050190084 creator A5055327692 @default.
- W2050190084 date "2012-02-01" @default.
- W2050190084 modified "2023-10-18" @default.
- W2050190084 title "From Rapid to Delayed and Remote Postconditioning: The Evolving Concept of Ischemic Postconditioning in Brain Ischemia" @default.
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