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• W2050191972 abstract "To assess the occurrence, severity and type of sleep disordered breathing in patients with acromegaly. Thirty three patients [5 males and 28 females, mean age – 55 (95% CI 51.1–61.2) years, body mass index 28.7 (95% CI 27.2–30.3) kg/m2] with active form of acromegaly lasting for 3 (95% CI 0.9–36.4) months on average (since the diagnosis was verified) underwent full polysomnography (Embla N7000, MedCare, USA). The assessment of sleep disordered breathing was performed according to the Scoring rules of American Academy of Sleep Medicine (2009). In eleven (34%) females [median age 46 (95% CI 35.7–61.2) years] apnea/hypopnea index (AHI) was less than 5 episodes per hour of sleep [median 3.2 (95% CI 1.7–4.4) episodes/h], in 6 subjects [one male and 5 females, median age 59 (95% CI 51.4–76.3) years] – 12.9 (95% CI 8.2–14.8) episodes/h. Two females aged 52 and 62 years (AHI 23.1 and 16 episodes/h) had moderate obstructive sleep apnea (OSA) and 14 patients [3 males and 11 females, median age 55 (95% CI 53.0–64.8) years] had severe sleep disordered breathing with median AHI 53 (95% CI 46.9–66.4) episodes/h (χ2 = 30; p < 0.001). Among them 12 subjects [3 males and 9 females, median age 59 (95% CI 53.9–67.6) years] demonstrated OSA, and 2 patients (one 50-year-old male and one 53-year-old female) had mixed apnea. Those with severe apnea had higher values of BMI that was 31.7 (95% CI 28.9–34.3); 28.4 (95% CI 24.4–31.7) and 25.5 (95% CI 23.8–28.0) kg/m2 in patients with severe, mild apnea and in subjects without sleep breathing disorders, respectively (χ2 = 8.7; p = 0.03). In two females with moderate sleep apnea BMI was 29.7 and 28.7 kg/m2. BMI positively correlated with the severity of sleep apnea (ρ = 0.8; p < 0.001) and negatively – with mean oxygen saturation (ρ = −0.9; p < 0.001) and the size of adenoma (ρ = −0.5; p < 0.05). Sleep disordered breathing, and mostly obstructive sleep apnea, are highly prevalent among patients with acromegaly, affecting almost 2/3 of patients that exceeds general population statistics. The severity of sleep disordered breathing is associated with BMI that might be a contributing factor, but the search for other potential contributing factors is required in this group of patients. Authors declare no conflict of interest." @default.
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• W2050191972 date "2013-12-01" @default.
• W2050191972 modified "2023-09-26" @default.
• W2050191972 title "Occurrence of sleep disordered breathing in acromegaly" @default.
• W2050191972 doi "https://doi.org/10.1016/j.sleep.2013.11.407" @default.
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