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• W2050200812 abstract "Platelet factor 4 (PF-4) belongs to a superfamily of low-molecular weight proteins known as chemokines. However, its function has not been fully evaluated. In the present study, we investigated the effect of PF-4 on histamine release from rat peritoneal mast cells by employing its biologically-active carboxyl-terminal fragment, PF-4 (58-70). PF-4 (58-70) stimulated histamine release from mast cells in a dose-dependent manner (10(-8) to 10(-5)M). Histamine release induced by PF-4 (58-70) occurred rapidly (<30s) and was inhibited by extracellular Ca(2+). These results suggest that PF-4 might play a crucial role at the site of inflammation and/or immune response." @default.
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• W2050200812 date "2002-10-01" @default.
• W2050200812 modified "2023-10-07" @default.
• W2050200812 title "Platelet factor 4 fragment induces histamine release from rat peritoneal mast cells" @default.
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• W2050200812 doi "https://doi.org/10.1016/s0196-9781(02)00143-2" @default.
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