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• W2050203464 abstract "Abstract Ataxia telangiectasia is a genetically transmitted disorder, characterized by progressive neurologic dysfunction, superficial telangiectasia, and abnormalities of cellular and humoral immunity. We examined a 13-year-old female with this disorder, whose peripheral T cells were found deficient in their ability to collaborate with B cells from unrelated normal individuals, but not from each of her parents and her sisters upon coculturing in the presence of pokeweed mitogen (PWM). In addition, the patient's T cells (Tp) suppressed the Ig production by PWM-stimulated peripheral blood lymphocytes (PBL) from allogeneic normal individuals but not from her parents. In contrast, irradiated T cells from this patient could collaborate to produce Ig with allogeneic B cells. HLA studies revealed that PWM-induced Ig production by PBL from the relatives was not suppressed by Tp irrespective of HLA phenotype of the donor. These data strongly suggest that Tp subpopulation has both a genetically unrestricted helper and a genetically restricted suppressor, a hitherto unreported phenomenon." @default.
• W2050203464 created "2016-06-24" @default.
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• W2050203464 date "1981-06-01" @default.
• W2050203464 modified "2023-10-18" @default.
• W2050203464 title "T-cell suppression of immunoglobulin synthesis in ataxia telangiectasia: Restriction of suppressor activity to B cells from unrelated donors" @default.
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• W2050203464 doi "https://doi.org/10.1016/0090-1229(81)90081-7" @default.
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