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• W2050203722 startingPage "339" @default.
• W2050203722 abstract "In cultures of Escherichia coli grown with excess tryptophan about seven of every eight RNA polymerase molecules that initiate transcription on the trp operon terminate in the leader region (Bertrand et al., 1976). Tryptophan starvation relieves this termination, allowing a greater fraction of initiating RNA polymerase molecules to proceed beyond the termination site into the structural genes of the operon. Isoleucine starvation does not have a similar effect. These findings suggest that tryptophan or a metabolic product of tryptophan functions as an effector in regulation at the termination site. None of the five major polypeptides specified by the operon appears to regulate termination of transcription in the leader region; the polypeptides are neither required for termination nor do they influence the relief of termination observed during tryptophan starvation." @default.
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• W2050203722 date "1976-05-01" @default.
• W2050203722 modified "2023-09-26" @default.
• W2050203722 title "Regulation of transcription termination in the leader region of the tryptophan operon of Escherichia coli involves tryptophan or its metabolic product" @default.
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• W2050203722 doi "https://doi.org/10.1016/0022-2836(76)90316-8" @default.
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