Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050209774> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2050209774 endingPage "177" @default.
- W2050209774 startingPage "170" @default.
- W2050209774 abstract "Radiation-induced heart disease (RIHD) is a severe side effect of thoracic radiotherapy. This study examined the effects of pentoxifylline (PTX) and alpha-tocopherol on cardiac injury in a rat model of RIHD.Male Sprague-Dawley rats received fractionated local heart irradiation with a daily dose of 9 Gy for 5 days and were observed for 6 months after irradiation. Rats were treated with a combination of PTX, 100 mg/kg/day, and alpha-tocopherol (20 IU/kg/day) and received these compounds either from 1 week before until 6 months after irradiation or starting 3 months after irradiation, a time point at which histopathologic changes become apparent in our model of RIHD.Radiation-induced increases in left ventricular diastolic pressure (in mm Hg: 35 +/- 6 after sham-irradiation, 82 +/- 11 after irradiation) were significantly reduced by PTX and alpha-tocopherol (early treatment: 48 +/- 7; late treatment: 53 +/- 6). PTX and alpha-tocopherol significantly reduced deposition of collagen types I (radiation only: 3.5 +/- 0.2 mum(2) per 100 mum(2); early treatment: 2.7 +/- 0.8; late treatment: 2.2 +/- 0.2) and III (radiation only: 13.9 +/- 0.8; early treatment: 11.0 +/- 1.2; late treatment: 10.6 +/- 0.8). On the other hand, radiation-induced alterations in heart/body weight ratios, myocardial degeneration, left ventricular mast cell densities, and most echocardiographic parameters were not significantly altered by PTX and alpha-tocopherol.Treatment with PTX and alpha-tocopherol may have beneficial effects on radiation-induced myocardial fibrosis and left ventricular function, both when started before irradiation and when started later during the process of RIHD." @default.
- W2050209774 created "2016-06-24" @default.
- W2050209774 creator A5014015669 @default.
- W2050209774 creator A5040127370 @default.
- W2050209774 creator A5088241361 @default.
- W2050209774 date "2008-09-01" @default.
- W2050209774 modified "2023-10-18" @default.
- W2050209774 title "Prevention and Treatment of Functional and Structural Radiation Injury in the Rat Heart by Pentoxifylline and Alpha-Tocopherol" @default.
- W2050209774 cites W1544227108 @default.
- W2050209774 cites W1618994470 @default.
- W2050209774 cites W1966655531 @default.
- W2050209774 cites W1967481867 @default.
- W2050209774 cites W1981413244 @default.
- W2050209774 cites W1983281361 @default.
- W2050209774 cites W1987124704 @default.
- W2050209774 cites W1990124576 @default.
- W2050209774 cites W1992421140 @default.
- W2050209774 cites W2001442729 @default.
- W2050209774 cites W2002478692 @default.
- W2050209774 cites W2010040965 @default.
- W2050209774 cites W2014690275 @default.
- W2050209774 cites W2035700687 @default.
- W2050209774 cites W2073522808 @default.
- W2050209774 cites W2077103009 @default.
- W2050209774 cites W2085143233 @default.
- W2050209774 cites W2102003700 @default.
- W2050209774 cites W2110365702 @default.
- W2050209774 cites W2130679532 @default.
- W2050209774 cites W2138605058 @default.
- W2050209774 cites W2139832361 @default.
- W2050209774 cites W2140492419 @default.
- W2050209774 cites W2143911442 @default.
- W2050209774 cites W2154939734 @default.
- W2050209774 cites W2156003808 @default.
- W2050209774 cites W277663757 @default.
- W2050209774 cites W2800860148 @default.
- W2050209774 cites W49033745 @default.
- W2050209774 doi "https://doi.org/10.1016/j.ijrobp.2008.04.042" @default.
- W2050209774 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574608" @default.
- W2050209774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18632215" @default.
- W2050209774 hasPublicationYear "2008" @default.
- W2050209774 type Work @default.
- W2050209774 sameAs 2050209774 @default.
- W2050209774 citedByCount "103" @default.
- W2050209774 countsByYear W20502097742012 @default.
- W2050209774 countsByYear W20502097742013 @default.
- W2050209774 countsByYear W20502097742014 @default.
- W2050209774 countsByYear W20502097742015 @default.
- W2050209774 countsByYear W20502097742016 @default.
- W2050209774 countsByYear W20502097742017 @default.
- W2050209774 countsByYear W20502097742018 @default.
- W2050209774 countsByYear W20502097742019 @default.
- W2050209774 countsByYear W20502097742020 @default.
- W2050209774 countsByYear W20502097742021 @default.
- W2050209774 countsByYear W20502097742022 @default.
- W2050209774 countsByYear W20502097742023 @default.
- W2050209774 crossrefType "journal-article" @default.
- W2050209774 hasAuthorship W2050209774A5014015669 @default.
- W2050209774 hasAuthorship W2050209774A5040127370 @default.
- W2050209774 hasAuthorship W2050209774A5088241361 @default.
- W2050209774 hasBestOaLocation W20502097742 @default.
- W2050209774 hasConcept C126322002 @default.
- W2050209774 hasConcept C134018914 @default.
- W2050209774 hasConcept C2780404050 @default.
- W2050209774 hasConcept C2989005 @default.
- W2050209774 hasConcept C509974204 @default.
- W2050209774 hasConcept C71924100 @default.
- W2050209774 hasConcept C90924648 @default.
- W2050209774 hasConceptScore W2050209774C126322002 @default.
- W2050209774 hasConceptScore W2050209774C134018914 @default.
- W2050209774 hasConceptScore W2050209774C2780404050 @default.
- W2050209774 hasConceptScore W2050209774C2989005 @default.
- W2050209774 hasConceptScore W2050209774C509974204 @default.
- W2050209774 hasConceptScore W2050209774C71924100 @default.
- W2050209774 hasConceptScore W2050209774C90924648 @default.
- W2050209774 hasIssue "1" @default.
- W2050209774 hasLocation W20502097741 @default.
- W2050209774 hasLocation W20502097742 @default.
- W2050209774 hasLocation W20502097743 @default.
- W2050209774 hasLocation W20502097744 @default.
- W2050209774 hasOpenAccess W2050209774 @default.
- W2050209774 hasPrimaryLocation W20502097741 @default.
- W2050209774 hasRelatedWork W1966504330 @default.
- W2050209774 hasRelatedWork W1979139803 @default.
- W2050209774 hasRelatedWork W1993860569 @default.
- W2050209774 hasRelatedWork W2030889776 @default.
- W2050209774 hasRelatedWork W2037631372 @default.
- W2050209774 hasRelatedWork W2040058909 @default.
- W2050209774 hasRelatedWork W2132898409 @default.
- W2050209774 hasRelatedWork W2748952813 @default.
- W2050209774 hasRelatedWork W4239576781 @default.
- W2050209774 hasRelatedWork W2521952050 @default.
- W2050209774 hasVolume "72" @default.
- W2050209774 isParatext "false" @default.
- W2050209774 isRetracted "false" @default.
- W2050209774 magId "2050209774" @default.
- W2050209774 workType "article" @default.