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- W2050215570 abstract "The nucleotide-binding domain leucine-rich repeat containing (NLR) family of receptors are members of the innate immune system, and have a critical role in host defense. These molecules are key to driving inflammatory responses to abnormal cellular conditions. Many NLRs serve this role on activation by forming a multiprotein complex called an inflammasome. The inflammasome drives the processing and release of cytokines, such as the proinflammatory cytokines interleukin (IL)-1β and IL-18. Recently, the important function of NLR molecules in autoinflammatory disorders has been recognized, in part through the identification of the role of IL-1β in the pathogenesis of several autoinflammatory diseases. Cryopyrin-associated periodic syndromes were the first autoinflammatory disorders found to be directly mediated by dysfunctional inflammasome activation. This finding has subsequently led to studies in both murine models and humans that have revealed several other inflammatory conditions associated with activation of NLR-containing inflammasomes. Understanding the molecular pathophysiology of these autoinflammatory disorders has further guided the successful development of targeted therapy against IL-1. In this review, we provide an overview of the inflammasomes and describe the important role they play in the development and manifestation of autoinflammatory diseases." @default.
- W2050215570 created "2016-06-24" @default.
- W2050215570 creator A5077549687 @default.
- W2050215570 creator A5088875170 @default.
- W2050215570 date "2010-09-01" @default.
- W2050215570 modified "2023-10-16" @default.
- W2050215570 title "Inflammasome-Mediated Autoinflammatory Disorders" @default.
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- W2050215570 cites W1542410645 @default.
- W2050215570 cites W1596257295 @default.
- W2050215570 cites W1600212999 @default.
- W2050215570 cites W1642457845 @default.
- W2050215570 cites W1670573097 @default.
- W2050215570 cites W1965086973 @default.
- W2050215570 cites W1968979867 @default.
- W2050215570 cites W1971133541 @default.
- W2050215570 cites W1973329998 @default.
- W2050215570 cites W1974781808 @default.
- W2050215570 cites W1977774202 @default.
- W2050215570 cites W1980442164 @default.
- W2050215570 cites W1983053357 @default.
- W2050215570 cites W1987609001 @default.
- W2050215570 cites W1993728991 @default.
- W2050215570 cites W1993819340 @default.
- W2050215570 cites W1996264333 @default.
- W2050215570 cites W1996341603 @default.
- W2050215570 cites W1996830451 @default.
- W2050215570 cites W2009004909 @default.
- W2050215570 cites W2009800174 @default.
- W2050215570 cites W2013946833 @default.
- W2050215570 cites W2018607502 @default.
- W2050215570 cites W2019635433 @default.
- W2050215570 cites W2020908160 @default.
- W2050215570 cites W2020964590 @default.
- W2050215570 cites W2024378513 @default.
- W2050215570 cites W2030110863 @default.
- W2050215570 cites W2030117347 @default.
- W2050215570 cites W2030672128 @default.
- W2050215570 cites W2041084308 @default.
- W2050215570 cites W2047868805 @default.
- W2050215570 cites W2050781159 @default.
- W2050215570 cites W2050798656 @default.
- W2050215570 cites W2051552252 @default.
- W2050215570 cites W2053114531 @default.
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- W2050215570 cites W2064027072 @default.
- W2050215570 cites W2080210471 @default.
- W2050215570 cites W2083062923 @default.
- W2050215570 cites W2086542111 @default.
- W2050215570 cites W2088164523 @default.
- W2050215570 cites W2089972348 @default.
- W2050215570 cites W2092360953 @default.
- W2050215570 cites W2093524746 @default.
- W2050215570 cites W2099808663 @default.
- W2050215570 cites W2100379211 @default.
- W2050215570 cites W2102429140 @default.
- W2050215570 cites W2105155669 @default.
- W2050215570 cites W2109824852 @default.
- W2050215570 cites W2111702848 @default.
- W2050215570 cites W2114769428 @default.
- W2050215570 cites W2115867185 @default.
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- W2050215570 cites W2126384811 @default.
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- W2050215570 cites W2134735862 @default.
- W2050215570 cites W2135791851 @default.
- W2050215570 cites W2141331384 @default.
- W2050215570 cites W2146527682 @default.
- W2050215570 cites W2149374693 @default.
- W2050215570 cites W2159905729 @default.
- W2050215570 cites W2160604747 @default.
- W2050215570 cites W2162515800 @default.
- W2050215570 cites W2164013854 @default.
- W2050215570 cites W2164448276 @default.
- W2050215570 cites W2164450207 @default.
- W2050215570 cites W2166227876 @default.
- W2050215570 cites W2242165656 @default.
- W2050215570 cites W4237101852 @default.
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- W2050215570 doi "https://doi.org/10.3810/pgm.2010.09.2209" @default.
- W2050215570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3648991" @default.
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