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• W2050216133 endingPage "e29021" @default.
• W2050216133 startingPage "e29021" @default.
• W2050216133 abstract "Progesterone, via its nuclear receptor (PR), exerts an overall tumorigenic effect on both uterine fibroid (leiomyoma) and breast cancer tissues, whereas the antiprogestin RU486 inhibits growth of these tissues through an unknown mechanism. Here, we determined the interaction between common or cell-specific genome-wide binding sites of PR and mRNA expression in RU486-treated uterine leiomyoma and breast cancer cells.ChIP-sequencing revealed 31,457 and 7,034 PR-binding sites in breast cancer and uterine leiomyoma cells, respectively; 1,035 sites overlapped in both cell types. Based on the chromatin-PR interaction in both cell types, we statistically refined the consensus progesterone response element to G•ACA• • •TGT•C. We identified two striking differences between uterine leiomyoma and breast cancer cells. First, the cis-regulatory elements for HSF, TEF-1, and C/EBPα and β were statistically enriched at genomic RU486/PR-targets in uterine leiomyoma, whereas E2F, FOXO1, FOXA1, and FOXF sites were preferentially enriched in breast cancer cells. Second, 51.5% of RU486-regulated genes in breast cancer cells but only 6.6% of RU486-regulated genes in uterine leiomyoma cells contained a PR-binding site within 5 kb from their transcription start sites (TSSs), whereas 75.4% of RU486-regulated genes contained a PR-binding site farther than 50 kb from their TSSs in uterine leiomyoma cells. RU486 regulated only seven mRNAs in both cell types. Among these, adipophilin (PLIN2), a pro-differentiation gene, was induced via RU486 and PR via the same regulatory region in both cell types.Our studies have identified molecular components in a RU486/PR-controlled gene network involved in the regulation of cell growth, cell migration, and extracellular matrix function. Tissue-specific and common patterns of genome-wide PR binding and gene regulation may determine the therapeutic effects of antiprogestins in uterine fibroids and breast cancer." @default.
• W2050216133 created "2016-06-24" @default.
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• W2050216133 date "2012-01-17" @default.
• W2050216133 modified "2023-09-27" @default.
• W2050216133 title "Genome-Wide Progesterone Receptor Binding: Cell Type-Specific and Shared Mechanisms in T47D Breast Cancer Cells and Primary Leiomyoma Cells" @default.
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• W2050216133 cites W1963928942 @default.
• W2050216133 cites W1969108518 @default.
• W2050216133 cites W1978921101 @default.
• W2050216133 cites W1982519328 @default.
• W2050216133 cites W1985336161 @default.
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• W2050216133 cites W2002357201 @default.
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• W2050216133 cites W2018092683 @default.
• W2050216133 cites W2025995094 @default.
• W2050216133 cites W2026448022 @default.
• W2050216133 cites W2026633715 @default.
• W2050216133 cites W2029564100 @default.
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• W2050216133 cites W2086189048 @default.
• W2050216133 cites W2093073704 @default.
• W2050216133 cites W2094036688 @default.
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• W2050216133 cites W2138976334 @default.
• W2050216133 cites W2145091349 @default.
• W2050216133 cites W2148153414 @default.
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• W2050216133 cites W2156853400 @default.
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• W2050216133 cites W2160760551 @default.
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• W2050216133 cites W2166037178 @default.
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• W2050216133 doi "https://doi.org/10.1371/journal.pone.0029021" @default.
• W2050216133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3260146" @default.
• W2050216133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22272226" @default.
• W2050216133 hasPublicationYear "2012" @default.
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