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• W2050228365 abstract "Investigations of preclinical biomarkers for major depressive disorder (MDD) encompass the quantification of proteins, peptides, mRNAs, or small molecules in blood or urine of animal models. Most studies aim at characterising the animal model by including the assessment of analytes or hormones affected in depressive patients. The ultimate objective is to validate the model to better understand the neurobiological basis of MDD. Stress hormones or inflammation-related analytes associated with MDD are frequently measured. In contrast, other investigators evaluate peripheral analytes in preclinical models to translate the results in clinical settings afterwards. Large-scale, hypothesis-free studies are performed in MDD models to identify candidate biomarkers. Other studies wish to propose new targets for drug discovery. Animal models endowed with predictive validity are investigated, and the assessment of peripheral analytes, such as stress hormones or immune molecules, is comprised to increase the confidence in the target. Finally, since the mechanism of action of antidepressants is incompletely understood, studies investigating molecular alterations associated with antidepressant treatment may include peripheral analyte levels. In conclusion, preclinical biomarker studies aid the identification of new candidate analytes to be tested in clinical trials. They also increase our understanding of MDD pathophysiology and help to identify new pharmacological targets." @default.
• W2050228365 created "2016-06-24" @default.
• W2050228365 creator A5002549616 @default.
• W2050228365 date "2013-01-01" @default.
• W2050228365 modified "2023-10-11" @default.
• W2050228365 title "Peripheral Biomarkers in Animal Models of Major Depressive Disorder" @default.
• W2050228365 cites W1509868652 @default.
• W2050228365 cites W1555141606 @default.
• W2050228365 cites W1964530395 @default.
• W2050228365 cites W1965655537 @default.
• W2050228365 cites W1966479610 @default.
• W2050228365 cites W1966603276 @default.
• W2050228365 cites W1969422800 @default.
• W2050228365 cites W1972193475 @default.
• W2050228365 cites W1976474511 @default.
• W2050228365 cites W1977657096 @default.
• W2050228365 cites W1978830885 @default.
• W2050228365 cites W1979468734 @default.
• W2050228365 cites W1979705133 @default.
• W2050228365 cites W1983295831 @default.
• W2050228365 cites W1986674928 @default.
• W2050228365 cites W1988225935 @default.
• W2050228365 cites W1988912854 @default.
• W2050228365 cites W1989369404 @default.
• W2050228365 cites W1991766265 @default.
• W2050228365 cites W1994672146 @default.
• W2050228365 cites W1996454121 @default.
• W2050228365 cites W1999682854 @default.
• W2050228365 cites W1999721747 @default.
• W2050228365 cites W2000779607 @default.
• W2050228365 cites W2003008123 @default.
• W2050228365 cites W2004267297 @default.
• W2050228365 cites W2004462939 @default.
• W2050228365 cites W2004762037 @default.
• W2050228365 cites W2007636259 @default.
• W2050228365 cites W2007816528 @default.
• W2050228365 cites W2009173112 @default.
• W2050228365 cites W2014435820 @default.
• W2050228365 cites W2015509887 @default.
• W2050228365 cites W2015536698 @default.
• W2050228365 cites W2017154881 @default.
• W2050228365 cites W2018430255 @default.
• W2050228365 cites W2023415096 @default.
• W2050228365 cites W2038051420 @default.
• W2050228365 cites W2038783721 @default.
• W2050228365 cites W2039923358 @default.
• W2050228365 cites W2040103405 @default.
• W2050228365 cites W2040500287 @default.
• W2050228365 cites W2040912840 @default.
• W2050228365 cites W2047126441 @default.
• W2050228365 cites W2049112128 @default.
• W2050228365 cites W2049479975 @default.
• W2050228365 cites W2050508296 @default.
• W2050228365 cites W2056292010 @default.
• W2050228365 cites W2056411950 @default.
• W2050228365 cites W2057670077 @default.
• W2050228365 cites W2057882325 @default.
• W2050228365 cites W2058805315 @default.
• W2050228365 cites W2068671706 @default.
• W2050228365 cites W2072847743 @default.
• W2050228365 cites W2073636547 @default.
• W2050228365 cites W2077183950 @default.
• W2050228365 cites W2079285312 @default.
• W2050228365 cites W2079819775 @default.
• W2050228365 cites W2079960444 @default.
• W2050228365 cites W2080032809 @default.
• W2050228365 cites W2086208662 @default.
• W2050228365 cites W2089198034 @default.
• W2050228365 cites W2089417699 @default.
• W2050228365 cites W2089617519 @default.
• W2050228365 cites W2091064703 @default.
• W2050228365 cites W2093219983 @default.
• W2050228365 cites W2098731039 @default.
• W2050228365 cites W2106623141 @default.
• W2050228365 cites W2117747224 @default.
• W2050228365 cites W2118710970 @default.
• W2050228365 cites W2121964796 @default.
• W2050228365 cites W2127465815 @default.
• W2050228365 cites W2128898116 @default.
• W2050228365 cites W2129579709 @default.
• W2050228365 cites W2137296158 @default.
• W2050228365 cites W2144269887 @default.
• W2050228365 cites W2150961207 @default.
• W2050228365 cites W2161000933 @default.
• W2050228365 cites W2182104458 @default.
• W2050228365 cites W4247090376 @default.
• W2050228365 doi "https://doi.org/10.1155/2013/284543" @default.
• W2050228365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774958" @default.
• W2050228365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24167347" @default.
• W2050228365 hasPublicationYear "2013" @default.
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