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- W2050229052 abstract "While hippocampal atrophy has been described during healthy aging, few studies have examined its relationship with the integrity of White Matter (WM) connecting tracts of the limbic system. This investigation examined WM structural damage specifically related to hippocampal atrophy in healthy aging subjects (n=129), using morphological MRI to assess hippocampal volume and Diffusion Tensor Imaging (DTI) to assess WM integrity. Subjects with Mild Cognitive Impairment (MCI) or dementia were excluded from the analysis. In our sample, increasing age was significantly associated with reduced hippocampal volume and reduced Fractional Anisotropy (FA) at the level of the fornix and the cingulum bundle. The findings also demonstrate that hippocampal atrophy was specifically associated with reduced FA of the fornix bundle, but it was not related to alteration of the cingulum bundle. Our results indicate that the relationship between hippocampal atrophy and fornix FA values is not due to an independent effect of age on both structures. A recursive regression procedure was applied to evaluate sequential relationships between the alterations of these two brain structures. When both hippocampal atrophy and fornix FA values were included in the same model to predict age, fornix FA values remained significant whereas hippocampal atrophy was no longer significantly associated with age. According to this latter finding, hippocampal atrophy in healthy aging could be mediated by a loss of fornix connections. Structural alterations of this part of the limbic system, which have been associated with neurodegeneration in Alzheimer’s disease, result at least in part from the aging process." @default.
- W2050229052 created "2016-06-24" @default.
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- W2050229052 date "2013-01-01" @default.
- W2050229052 modified "2023-10-18" @default.
- W2050229052 title "Structural hippocampal network alterations during healthy aging: a multi-modal MRI study" @default.
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- W2050229052 cites W1901020111 @default.
- W2050229052 cites W1968256939 @default.
- W2050229052 cites W1968471282 @default.
- W2050229052 cites W1969563318 @default.
- W2050229052 cites W1976676059 @default.
- W2050229052 cites W1978946251 @default.
- W2050229052 cites W1980225806 @default.
- W2050229052 cites W1983906797 @default.
- W2050229052 cites W1984167936 @default.
- W2050229052 cites W1986909933 @default.
- W2050229052 cites W1987574813 @default.
- W2050229052 cites W1988966433 @default.
- W2050229052 cites W1989028533 @default.
- W2050229052 cites W2000245563 @default.
- W2050229052 cites W2003428745 @default.
- W2050229052 cites W2015391962 @default.
- W2050229052 cites W2017375738 @default.
- W2050229052 cites W2018670600 @default.
- W2050229052 cites W2020471459 @default.
- W2050229052 cites W2027812607 @default.
- W2050229052 cites W2038568172 @default.
- W2050229052 cites W2039130870 @default.
- W2050229052 cites W2045892248 @default.
- W2050229052 cites W2046206944 @default.
- W2050229052 cites W2046557060 @default.
- W2050229052 cites W2047205872 @default.
- W2050229052 cites W2050214509 @default.
- W2050229052 cites W2051780893 @default.
- W2050229052 cites W2061082762 @default.
- W2050229052 cites W2062482581 @default.
- W2050229052 cites W2076094243 @default.
- W2050229052 cites W2077025340 @default.
- W2050229052 cites W2082077388 @default.
- W2050229052 cites W2082533002 @default.
- W2050229052 cites W2083234722 @default.
- W2050229052 cites W2084777187 @default.
- W2050229052 cites W2089940272 @default.
- W2050229052 cites W2091931051 @default.
- W2050229052 cites W2096181156 @default.
- W2050229052 cites W2099298482 @default.
- W2050229052 cites W2100651338 @default.
- W2050229052 cites W2102307380 @default.
- W2050229052 cites W2102391253 @default.
- W2050229052 cites W2104004753 @default.
- W2050229052 cites W2106841463 @default.
- W2050229052 cites W2113176889 @default.
- W2050229052 cites W2117950871 @default.
- W2050229052 cites W2118416442 @default.
- W2050229052 cites W2118421222 @default.
- W2050229052 cites W2118811112 @default.
- W2050229052 cites W2119848633 @default.
- W2050229052 cites W2122025249 @default.
- W2050229052 cites W2124648012 @default.
- W2050229052 cites W2128938428 @default.
- W2050229052 cites W2140306145 @default.
- W2050229052 cites W2140405850 @default.
- W2050229052 cites W2144749242 @default.
- W2050229052 cites W2148828979 @default.
- W2050229052 cites W2151712416 @default.
- W2050229052 cites W2154749730 @default.
- W2050229052 cites W2157416086 @default.
- W2050229052 cites W2157481067 @default.
- W2050229052 cites W2168247374 @default.
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- W2050229052 doi "https://doi.org/10.3389/fnagi.2013.00084" @default.
- W2050229052 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3852215" @default.
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