FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050239263> ?p ?o ?g. }

• W2050239263 endingPage "2875" @default.
• W2050239263 startingPage "2875" @default.
• W2050239263 abstract "The present study reports a new three-dimensional (3D) microfluidic platform capable of rapid isolation and detection of cancer cells from a large sample volume (e.g. ~1 mL) by utilizing magnetic microbead-based technologies. Several modules, including a 3D microfluidic incubator for the magnetic beads to capture cancer cells, a microfluidic control module for sample transportation and a nucleic acid amplification module for genetic identification, are integrated into this microsystem. With the incorporation of surface-modified magnetic beads, target cancer cells can be specifically recognized and conjugated onto the surface of the antibody-coated magnetic microbeads by utilizing a swirling effect generated by the new 3D microfluidic incubator, followed by isolating and purifying the magnetic complexes via the incorporation of an external magnet and a microfluidic control module, which washes away any unbound waste solution. Experimental results show that over 90% of the target cancer cells can be isolated from a large volume of bio-samples within 10 min in the 3D microfluidic incubator. In addition, the expressed genes associated with ovarian and lung cancer cells can also be successfully amplified by using the on-chip nucleic acid amplification module. More importantly, the detection limit of the developed system is found to be 5 × 10(1) cells mL(-1) for the target cancer cells, indicating that this proposed microfluidic system may be adapted for clinical use for the early detection of cancer cells. Consequently, the proposed 3D microfluidic system incorporated with immunomagnetic beads may provide a promising automated platform for the rapid isolation and detection of cancer cells with a high sensitivity." @default.
• W2050239263 created "2016-06-24" @default.
• W2050239263 creator A5007513075 @default.
• W2050239263 creator A5018402939 @default.
• W2050239263 creator A5018989378 @default.
• W2050239263 creator A5038414832 @default.
• W2050239263 creator A5050173955 @default.
• W2050239263 creator A5072339927 @default.
• W2050239263 creator A5073351431 @default.
• W2050239263 creator A5079914346 @default.
• W2050239263 date "2010-01-01" @default.
• W2050239263 modified "2023-10-16" @default.
• W2050239263 title "Rapid isolation and detection of cancer cells by utilizing integrated microfluidic systems" @default.
• W2050239263 cites W1506680628 @default.
• W2050239263 cites W1558034062 @default.
• W2050239263 cites W1645530958 @default.
• W2050239263 cites W1964597866 @default.
• W2050239263 cites W1968562444 @default.
• W2050239263 cites W1968800206 @default.
• W2050239263 cites W1970651807 @default.
• W2050239263 cites W1972867200 @default.
• W2050239263 cites W1985410622 @default.
• W2050239263 cites W1987561076 @default.
• W2050239263 cites W1987572677 @default.
• W2050239263 cites W1992623234 @default.
• W2050239263 cites W1997313982 @default.
• W2050239263 cites W1998854286 @default.
• W2050239263 cites W2008638508 @default.
• W2050239263 cites W2022200777 @default.
• W2050239263 cites W2024286012 @default.
• W2050239263 cites W2033117797 @default.
• W2050239263 cites W2037861870 @default.
• W2050239263 cites W2038554735 @default.
• W2050239263 cites W2042230030 @default.
• W2050239263 cites W2043861488 @default.
• W2050239263 cites W2046072531 @default.
• W2050239263 cites W2050547995 @default.
• W2050239263 cites W2051572649 @default.
• W2050239263 cites W2072741204 @default.
• W2050239263 cites W2079812848 @default.
• W2050239263 cites W2080416055 @default.
• W2050239263 cites W2082544764 @default.
• W2050239263 cites W2082766933 @default.
• W2050239263 cites W2087096498 @default.
• W2050239263 cites W2087545366 @default.
• W2050239263 cites W2087979050 @default.
• W2050239263 cites W2095259408 @default.
• W2050239263 cites W2102984786 @default.
• W2050239263 cites W2104666869 @default.
• W2050239263 cites W2105848478 @default.
• W2050239263 cites W2110141569 @default.
• W2050239263 cites W2110463021 @default.
• W2050239263 cites W2112143589 @default.
• W2050239263 cites W2146355187 @default.
• W2050239263 cites W2152238532 @default.
• W2050239263 cites W2160738932 @default.
• W2050239263 cites W2164216532 @default.
• W2050239263 cites W2170275996 @default.
• W2050239263 doi "https://doi.org/10.1039/c005178k" @default.
• W2050239263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20927448" @default.
• W2050239263 hasPublicationYear "2010" @default.
• W2050239263 type Work @default.
• W2050239263 sameAs 2050239263 @default.
• W2050239263 citedByCount "54" @default.
• W2050239263 countsByYear W20502392632012 @default.
• W2050239263 countsByYear W20502392632013 @default.
• W2050239263 countsByYear W20502392632014 @default.
• W2050239263 countsByYear W20502392632015 @default.
• W2050239263 countsByYear W20502392632016 @default.
• W2050239263 countsByYear W20502392632017 @default.
• W2050239263 countsByYear W20502392632018 @default.
• W2050239263 countsByYear W20502392632020 @default.
• W2050239263 countsByYear W20502392632021 @default.
• W2050239263 countsByYear W20502392632022 @default.
• W2050239263 countsByYear W20502392632023 @default.
• W2050239263 crossrefType "journal-article" @default.
• W2050239263 hasAuthorship W2050239263A5007513075 @default.
• W2050239263 hasAuthorship W2050239263A5018402939 @default.
• W2050239263 hasAuthorship W2050239263A5018989378 @default.
• W2050239263 hasAuthorship W2050239263A5038414832 @default.
• W2050239263 hasAuthorship W2050239263A5050173955 @default.
• W2050239263 hasAuthorship W2050239263A5072339927 @default.
• W2050239263 hasAuthorship W2050239263A5073351431 @default.
• W2050239263 hasAuthorship W2050239263A5079914346 @default.
• W2050239263 hasConcept C119128265 @default.
• W2050239263 hasConcept C121608353 @default.
• W2050239263 hasConcept C151054161 @default.
• W2050239263 hasConcept C171250308 @default.
• W2050239263 hasConcept C185592680 @default.
• W2050239263 hasConcept C192562407 @default.
• W2050239263 hasConcept C24107716 @default.
• W2050239263 hasConcept C2775941552 @default.
• W2050239263 hasConcept C2776363448 @default.
• W2050239263 hasConcept C2779013556 @default.
• W2050239263 hasConcept C2993110782 @default.
• W2050239263 hasConcept C43617362 @default.
• W2050239263 hasConcept C54355233 @default.
• W2050239263 hasConcept C55493867 @default.

• next