FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050242465> ?p ?o ?g. }

• W2050242465 endingPage "363" @default.
• W2050242465 startingPage "352" @default.
• W2050242465 abstract "F-BAR domains control membrane interactions in endocytosis, cytokinesis, and cell signaling. Although they are generally thought to bind curved membranes containing negatively charged phospholipids, numerous functional studies argue that differences in lipid-binding selectivities of F-BAR domains are functionally important. Here, we compare membrane-binding properties of the Saccharomyces cerevisiae F-BAR domains in vitro and in vivo. Whereas some F-BAR domains (such as Bzz1p and Hof1p F-BARs) bind equally well to all phospholipids, the F-BAR domain from the RhoGAP Rgd1p preferentially binds phosphoinositides. We determined X-ray crystal structures of F-BAR domains from Hof1p and Rgd1p, the latter bound to an inositol phosphate. The structures explain phospholipid-binding selectivity differences and reveal an F-BAR phosphoinositide binding site that is fully conserved in a mammalian RhoGAP called Gmip and is partly retained in certain other F-BAR domains. Our findings reveal previously unappreciated determinants of F-BAR domain lipid-binding specificity and provide a basis for its prediction from sequence." @default.
• W2050242465 created "2016-06-24" @default.
• W2050242465 creator A5009352398 @default.
• W2050242465 creator A5016119932 @default.
• W2050242465 creator A5028465682 @default.
• W2050242465 creator A5034135354 @default.
• W2050242465 creator A5054099984 @default.
• W2050242465 creator A5073959537 @default.
• W2050242465 creator A5079741827 @default.
• W2050242465 date "2015-02-01" @default.
• W2050242465 modified "2023-10-18" @default.
• W2050242465 title "Comparison of Saccharomyces cerevisiae F-BAR Domain Structures Reveals a Conserved Inositol Phosphate Binding Site" @default.
• W2050242465 cites W103677414 @default.
• W2050242465 cites W1539796472 @default.
• W2050242465 cites W1559736598 @default.
• W2050242465 cites W1781531090 @default.
• W2050242465 cites W1948844441 @default.
• W2050242465 cites W1965277349 @default.
• W2050242465 cites W1971637722 @default.
• W2050242465 cites W1972974751 @default.
• W2050242465 cites W1980207200 @default.
• W2050242465 cites W1981559490 @default.
• W2050242465 cites W1983732912 @default.
• W2050242465 cites W1990380758 @default.
• W2050242465 cites W1993419321 @default.
• W2050242465 cites W1993486015 @default.
• W2050242465 cites W1995017064 @default.
• W2050242465 cites W1999768397 @default.
• W2050242465 cites W2001511903 @default.
• W2050242465 cites W2001641653 @default.
• W2050242465 cites W2004344365 @default.
• W2050242465 cites W2004972894 @default.
• W2050242465 cites W2008264122 @default.
• W2050242465 cites W2010733852 @default.
• W2050242465 cites W2011625746 @default.
• W2050242465 cites W2019841520 @default.
• W2050242465 cites W2021804769 @default.
• W2050242465 cites W2027242569 @default.
• W2050242465 cites W2030517878 @default.
• W2050242465 cites W2031727992 @default.
• W2050242465 cites W2034452896 @default.
• W2050242465 cites W2041848251 @default.
• W2050242465 cites W2042646237 @default.
• W2050242465 cites W2043312574 @default.
• W2050242465 cites W2046963712 @default.
• W2050242465 cites W2052288973 @default.
• W2050242465 cites W2053527054 @default.
• W2050242465 cites W2058037188 @default.
• W2050242465 cites W2059311099 @default.
• W2050242465 cites W2060989256 @default.
• W2050242465 cites W2067626572 @default.
• W2050242465 cites W2072070715 @default.
• W2050242465 cites W2077084337 @default.
• W2050242465 cites W2077217909 @default.
• W2050242465 cites W2086636140 @default.
• W2050242465 cites W2090195270 @default.
• W2050242465 cites W2092954353 @default.
• W2050242465 cites W2095166308 @default.
• W2050242465 cites W2095662233 @default.
• W2050242465 cites W2099406730 @default.
• W2050242465 cites W2108586733 @default.
• W2050242465 cites W2110652912 @default.
• W2050242465 cites W2112200653 @default.
• W2050242465 cites W2119260049 @default.
• W2050242465 cites W2120179502 @default.
• W2050242465 cites W2124881029 @default.
• W2050242465 cites W2130587565 @default.
• W2050242465 cites W2137089508 @default.
• W2050242465 cites W2137525183 @default.
• W2050242465 cites W2141206157 @default.
• W2050242465 cites W2143694829 @default.
• W2050242465 cites W2144081223 @default.
• W2050242465 cites W2144996654 @default.
• W2050242465 cites W2150857270 @default.
• W2050242465 cites W2152159726 @default.
• W2050242465 cites W2166910344 @default.
• W2050242465 cites W2167852809 @default.
• W2050242465 cites W2170280114 @default.
• W2050242465 cites W2180229411 @default.
• W2050242465 cites W4233751197 @default.
• W2050242465 cites W4238658571 @default.
• W2050242465 cites W4302393627 @default.
• W2050242465 doi "https://doi.org/10.1016/j.str.2014.12.009" @default.
• W2050242465 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4319572" @default.
• W2050242465 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25620000" @default.
• W2050242465 hasPublicationYear "2015" @default.
• W2050242465 type Work @default.
• W2050242465 sameAs 2050242465 @default.
• W2050242465 citedByCount "35" @default.
• W2050242465 countsByYear W20502424652015 @default.
• W2050242465 countsByYear W20502424652016 @default.
• W2050242465 countsByYear W20502424652017 @default.
• W2050242465 countsByYear W20502424652018 @default.
• W2050242465 countsByYear W20502424652019 @default.
• W2050242465 countsByYear W20502424652020 @default.
• W2050242465 countsByYear W20502424652021 @default.
• W2050242465 countsByYear W20502424652022 @default.
• W2050242465 crossrefType "journal-article" @default.

• next