FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050249432> ?p ?o ?g. }

• W2050249432 endingPage "560" @default.
• W2050249432 startingPage "555" @default.
• W2050249432 abstract "Objectives: Intensive blood glucose control to a target value of 80–110 mg/dL has been shown to reduce morbidity and mortality in surgical intensive care unit patients. This was attributed predominantly to correction of hyperglycemia, based on multivariate regression analysis. However, the effects of glucose and insulin have not been independently evaluated. This study investigated the development of hepatic oxidative processes and systemic inflammatory response in rats with different levels of induced hyperglycemia and hyperinsulinemia. The effects of a modest increase in blood glucose following glucose infusion at a level adequate to meet energy requirements, hyperinsulinemia induced by a hyperinsulinemic euglycemic clamp with administered glucose in similar amounts, and marked hyperglycemia and hyperinsulinemia secondary to glucose infusion on hepatic oxidative stress and systemic inflammatory response in vivo were examined. Design: Controlled laboratory study. Setting: Medical school laboratory. Subjects: Specific pathogen-free male Sprague-Dawley rats. Interventions: Blood glucose was monitored over 3 hrs. At the end of study, the serum concentrations of insulin, tumor necrosis factor-α, interleukin-1, and α1 acid glycoprotein were determined. Malondialdehyde and total glutathione content were measured in the liver. Measurements and Main Results: Glucose infusion adequate to provide energy requirements resulted in a modest increase in blood glucose (143 ± 8 mg/dL) and hyperinsulinemia (45 μU/mL) and did not induce measurable hepatic oxidative stress or systemic inflammation. A hyperinsulinemic euglycemic clamp (insulin 112 ± 9 μU/mL) resulted in evidence of increased oxidative processes in the liver but no change in hepatic antioxidant capacity or evidence of systemic inflammation. When hyperglycemia (∼350 mg/dL) and hyperinsulinemia (167 ± 9 μU/mL) were induced by excess glucose infusion, rats manifested hepatic oxidative stress, antioxidant depletion, and a mild systemic inflammatory response. Conclusions: Hyperglycemia is a major cause of the systemic inflammatory response. Maintaining normal blood glucose, by avoiding overfeeding and providing insulin therapy when necessary, appears key to minimizing oxidative stress and systemic inflammation when intravenous nutrition is provided." @default.
• W2050249432 created "2016-06-24" @default.
• W2050249432 creator A5009775070 @default.
• W2050249432 creator A5057426767 @default.
• W2050249432 creator A5065239213 @default.
• W2050249432 date "2007-02-01" @default.
• W2050249432 modified "2023-10-11" @default.
• W2050249432 title "Acute effects of hyperglycemia and hyperinsulinemia on hepatic oxidative stress and the systemic inflammatory response in rats" @default.
• W2050249432 cites W1918973138 @default.
• W2050249432 cites W1971362133 @default.
• W2050249432 cites W1975586412 @default.
• W2050249432 cites W1980717583 @default.
• W2050249432 cites W1994574205 @default.
• W2050249432 cites W2003523555 @default.
• W2050249432 cites W2007005354 @default.
• W2050249432 cites W2009363604 @default.
• W2050249432 cites W2013845430 @default.
• W2050249432 cites W2030417531 @default.
• W2050249432 cites W2037187855 @default.
• W2050249432 cites W2037421018 @default.
• W2050249432 cites W2040505445 @default.
• W2050249432 cites W2066020920 @default.
• W2050249432 cites W2066054136 @default.
• W2050249432 cites W2078944084 @default.
• W2050249432 cites W2106015379 @default.
• W2050249432 cites W2107182330 @default.
• W2050249432 cites W2118877036 @default.
• W2050249432 cites W2129256561 @default.
• W2050249432 cites W2146742006 @default.
• W2050249432 cites W2150481072 @default.
• W2050249432 cites W2153797916 @default.
• W2050249432 cites W2162877252 @default.
• W2050249432 cites W2163567504 @default.
• W2050249432 cites W2165261525 @default.
• W2050249432 cites W2169968309 @default.
• W2050249432 cites W2336916859 @default.
• W2050249432 doi "https://doi.org/10.1097/01.ccm.0000253310.02180.c2" @default.
• W2050249432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17205027" @default.
• W2050249432 hasPublicationYear "2007" @default.
• W2050249432 type Work @default.
• W2050249432 sameAs 2050249432 @default.
• W2050249432 citedByCount "37" @default.
• W2050249432 countsByYear W20502494322012 @default.
• W2050249432 countsByYear W20502494322013 @default.
• W2050249432 countsByYear W20502494322014 @default.
• W2050249432 countsByYear W20502494322016 @default.
• W2050249432 countsByYear W20502494322017 @default.
• W2050249432 countsByYear W20502494322018 @default.
• W2050249432 countsByYear W20502494322020 @default.
• W2050249432 countsByYear W20502494322021 @default.
• W2050249432 countsByYear W20502494322022 @default.
• W2050249432 countsByYear W20502494322023 @default.
• W2050249432 crossrefType "journal-article" @default.
• W2050249432 hasAuthorship W2050249432A5009775070 @default.
• W2050249432 hasAuthorship W2050249432A5057426767 @default.
• W2050249432 hasAuthorship W2050249432A5065239213 @default.
• W2050249432 hasConcept C126322002 @default.
• W2050249432 hasConcept C134018914 @default.
• W2050249432 hasConcept C2776151105 @default.
• W2050249432 hasConcept C2776252253 @default.
• W2050249432 hasConcept C2776914184 @default.
• W2050249432 hasConcept C2777368190 @default.
• W2050249432 hasConcept C2777391703 @default.
• W2050249432 hasConcept C2778401633 @default.
• W2050249432 hasConcept C2778808658 @default.
• W2050249432 hasConcept C2779306644 @default.
• W2050249432 hasConcept C2780352109 @default.
• W2050249432 hasConcept C2780988686 @default.
• W2050249432 hasConcept C71924100 @default.
• W2050249432 hasConceptScore W2050249432C126322002 @default.
• W2050249432 hasConceptScore W2050249432C134018914 @default.
• W2050249432 hasConceptScore W2050249432C2776151105 @default.
• W2050249432 hasConceptScore W2050249432C2776252253 @default.
• W2050249432 hasConceptScore W2050249432C2776914184 @default.
• W2050249432 hasConceptScore W2050249432C2777368190 @default.
• W2050249432 hasConceptScore W2050249432C2777391703 @default.
• W2050249432 hasConceptScore W2050249432C2778401633 @default.
• W2050249432 hasConceptScore W2050249432C2778808658 @default.
• W2050249432 hasConceptScore W2050249432C2779306644 @default.
• W2050249432 hasConceptScore W2050249432C2780352109 @default.
• W2050249432 hasConceptScore W2050249432C2780988686 @default.
• W2050249432 hasConceptScore W2050249432C71924100 @default.
• W2050249432 hasIssue "2" @default.
• W2050249432 hasLocation W20502494321 @default.
• W2050249432 hasLocation W20502494322 @default.
• W2050249432 hasOpenAccess W2050249432 @default.
• W2050249432 hasPrimaryLocation W20502494321 @default.
• W2050249432 hasRelatedWork W1998097052 @default.
• W2050249432 hasRelatedWork W2047831454 @default.
• W2050249432 hasRelatedWork W2056982971 @default.
• W2050249432 hasRelatedWork W2164456008 @default.
• W2050249432 hasRelatedWork W2388039409 @default.
• W2050249432 hasRelatedWork W2397596616 @default.
• W2050249432 hasRelatedWork W2606816724 @default.
• W2050249432 hasRelatedWork W2800513205 @default.
• W2050249432 hasRelatedWork W4387080298 @default.
• W2050249432 hasRelatedWork W86011634 @default.
• W2050249432 hasVolume "35" @default.

• next