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- W2050249966 abstract "Background Innovation in mAb production is driven by strategies to increase yield. A host cell line constructed to overexpress TAUT (taurine transporter) produced a higher proportion of high-mAb-titer strains [1]. From these we selected a single TAUT/mAb strain that remained viable for as long as 1 month. Its improved viability is attributed to improved metabolic properties. It was also more productive (>100 pg/cell/day) and yielded more mAb (up to 8.1 g/L/31 days) than the parent cell line [2]. These results suggested that this host cell engineering strategy has great potential for the improvement of mAb-producing CHO cells." @default.
- W2050249966 created "2016-06-24" @default.
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- W2050249966 date "2013-12-01" @default.
- W2050249966 modified "2023-09-25" @default.
- W2050249966 title "Novel strategy for a high-yielding mAb-producing CHO strain (overexpression of non-coding RNA enhanced proliferation and improved mAb yield)" @default.
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- W2050249966 doi "https://doi.org/10.1186/1753-6561-7-s6-o3" @default.
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