FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2050249989> ?p ?o ?g. }

• W2050249989 endingPage "e54757" @default.
• W2050249989 startingPage "e54757" @default.
• W2050249989 abstract "The caudal-related homeodomain transcription factors Cdx1 and Cdx2 are expressed in the developing endoderm with expression persisting into adulthood. Cdx1−/− mutants are viable and fertile and display no overt intestinal phenotype. Cdx2 null mutants are peri-implantation lethal; however, conditional mutation approaches have revealed that Cdx2 is required for patterning the intestinal epithelium and specification of the colon. Cdx2 is also necessary for homeostasis of the intestinal tract in the adult, where Cdx1 and Cdx2 appear to functionally overlap in the distal colon, but not during intestinal development. Cdx1 and Cdx2 exhibit complete overlap of expression in the intestine, although they differ in their relative levels, with Cdx1 maximal in the distal colon and Cdx2 peaking in the proximal cecum. Moreover, Cdx1 protein is graded along the crypt-villus axis, being abundant in the crypts and diminishing towards the villi. Cdx2 is expressed uniformly along this axis, but is differentially phosphorylated; the functional relevance of these expression domains and phosphorylation is currently unknown. Cdx1 and Cdx2 have been suggested to exhibit functional specificity in the intestinal tract. In the present study, using cell-based models, we found that relative to Cdx1, Cdx2 was significantly less potent at effecting a transcriptional response from the Cdx1 promoter, a known Cdx target gene. We subsequently assessed this relationship in vivo using a “gene swap” approach and found that Cdx2 cannot substitute for Cdx1 in this autoregulatory loop. This is in marked contrast with the ability of Cdx2 to support Cdx1 expression and function in paraxial mesoderm and vertebral patterning, thus providing novel in vivo evidence of context-dependent transcriptional specificity between these transcription factors." @default.
• W2050249989 created "2016-06-24" @default.
• W2050249989 creator A5027057361 @default.
• W2050249989 creator A5035096769 @default.
• W2050249989 creator A5077969542 @default.
• W2050249989 date "2013-01-30" @default.
• W2050249989 modified "2023-10-15" @default.
• W2050249989 title "Cdx1 and Cdx2 Exhibit Transcriptional Specificity in the Intestine" @default.
• W2050249989 cites W1500070160 @default.
• W2050249989 cites W1519949493 @default.
• W2050249989 cites W1819918826 @default.
• W2050249989 cites W1963722699 @default.
• W2050249989 cites W1965514484 @default.
• W2050249989 cites W1969770877 @default.
• W2050249989 cites W1974835491 @default.
• W2050249989 cites W1976392356 @default.
• W2050249989 cites W1982533604 @default.
• W2050249989 cites W1982603620 @default.
• W2050249989 cites W1987865998 @default.
• W2050249989 cites W1991439294 @default.
• W2050249989 cites W1991592461 @default.
• W2050249989 cites W1992361419 @default.
• W2050249989 cites W2001066109 @default.
• W2050249989 cites W2003880876 @default.
• W2050249989 cites W2004761710 @default.
• W2050249989 cites W2009009612 @default.
• W2050249989 cites W2025468425 @default.
• W2050249989 cites W2026046334 @default.
• W2050249989 cites W2043880988 @default.
• W2050249989 cites W2045265674 @default.
• W2050249989 cites W2062430722 @default.
• W2050249989 cites W2065546267 @default.
• W2050249989 cites W2065685304 @default.
• W2050249989 cites W2065883417 @default.
• W2050249989 cites W2080342872 @default.
• W2050249989 cites W2081021575 @default.
• W2050249989 cites W2099073211 @default.
• W2050249989 cites W2102434502 @default.
• W2050249989 cites W2107090295 @default.
• W2050249989 cites W2109293927 @default.
• W2050249989 cites W2110075345 @default.
• W2050249989 cites W2112105989 @default.
• W2050249989 cites W2112307229 @default.
• W2050249989 cites W2113284270 @default.
• W2050249989 cites W2114719481 @default.
• W2050249989 cites W2117688088 @default.
• W2050249989 cites W2120662540 @default.
• W2050249989 cites W2124620770 @default.
• W2050249989 cites W2128665076 @default.
• W2050249989 cites W2134959578 @default.
• W2050249989 cites W2136303658 @default.
• W2050249989 cites W2143973293 @default.
• W2050249989 cites W2144277963 @default.
• W2050249989 cites W2145955680 @default.
• W2050249989 cites W2146010982 @default.
• W2050249989 cites W2150094792 @default.
• W2050249989 cites W2150758899 @default.
• W2050249989 cites W2153886104 @default.
• W2050249989 cites W2156188585 @default.
• W2050249989 cites W2156667412 @default.
• W2050249989 cites W2159783062 @default.
• W2050249989 cites W4210742039 @default.
• W2050249989 cites W4293247451 @default.
• W2050249989 doi "https://doi.org/10.1371/journal.pone.0054757" @default.
• W2050249989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3559873" @default.
• W2050249989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23382958" @default.
• W2050249989 hasPublicationYear "2013" @default.
• W2050249989 type Work @default.
• W2050249989 sameAs 2050249989 @default.
• W2050249989 citedByCount "20" @default.
• W2050249989 countsByYear W20502499892014 @default.
• W2050249989 countsByYear W20502499892015 @default.
• W2050249989 countsByYear W20502499892016 @default.
• W2050249989 countsByYear W20502499892017 @default.
• W2050249989 countsByYear W20502499892019 @default.
• W2050249989 countsByYear W20502499892020 @default.
• W2050249989 countsByYear W20502499892021 @default.
• W2050249989 countsByYear W20502499892022 @default.
• W2050249989 crossrefType "journal-article" @default.
• W2050249989 hasAuthorship W2050249989A5027057361 @default.
• W2050249989 hasAuthorship W2050249989A5035096769 @default.
• W2050249989 hasAuthorship W2050249989A5077969542 @default.
• W2050249989 hasBestOaLocation W20502499891 @default.
• W2050249989 hasConcept C104317684 @default.
• W2050249989 hasConcept C121587040 @default.
• W2050249989 hasConcept C131364181 @default.
• W2050249989 hasConcept C145103041 @default.
• W2050249989 hasConcept C2780915607 @default.
• W2050249989 hasConcept C2781077229 @default.
• W2050249989 hasConcept C529295009 @default.
• W2050249989 hasConcept C54355233 @default.
• W2050249989 hasConcept C61342607 @default.
• W2050249989 hasConcept C86339819 @default.
• W2050249989 hasConcept C86803240 @default.
• W2050249989 hasConcept C95444343 @default.
• W2050249989 hasConceptScore W2050249989C104317684 @default.
• W2050249989 hasConceptScore W2050249989C121587040 @default.
• W2050249989 hasConceptScore W2050249989C131364181 @default.

• next